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Murine Gammaherpesvirus 68: A Small Animal Model for Gammaherpesvirus-Associated Diseases

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Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1018)

Abstract

Murine gammaherpesvirus 68 (MHV68) is a naturally occurring pathogen of murid rodents that is genetically related to the human gammaherpesviruses Epstein-Barr virus (EBV) and Kaposi sarcoma-associated herpesvirus (KSHV). Viral, immunologic, and disease parameters following experimental infection of laboratory mice with MHV68 closely resemble what occurs during primary EBV infection of humans, which suggests that MHV68 infection of mice offers a small animal model to study in general the pathogenesis of gammaherpesvirus infections. Diseases elicited by MHV68 infection include lymphoproliferative diseases, idiopathic pulmonary fibrosis, and autoimmune diseases, ailments also associated with EBV infection of humans. Furthermore, MHV68 infection also is linked to the development of vasculitis, encephalomyelitis, and other disorders that resemble pathologies with viral and nonviral etiologies in humans. This review aims to provide an overview of MHV68-associated diseases in infected mice that may provide a model for understanding basic mechanisms by which similar diseases in humans occur and can be treated.

Keywords

Animal model Murine gammaherpesvirus 68 Epstein-Barr virus Kaposi sarcoma-associated herpesvirus 
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Notes

Acknowledgments

This work was supported by the grant (CA167065, J.C.F) from the National Cancer Institute of the National Institutes of Health and the grant (81371825, X.Z.L) from Natural Science Foundation of China.

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© Springer Nature Singapore Pte Ltd. 2017

Authors and Affiliations

  1. 1.Key Laboratory of Molecular Virology & ImmunologyInstitut Pasteur of Shanghai, Chinese Academy of SciencesShanghaiPeople’s Republic of China
  2. 2.Department of Microbiology and Immunology and Center for Microbial Pathogenesis and Host Inflammatory ResponsesUniversity of Arkansas for Medical SciencesLittle RockUSA

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