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Translational Informatics in Smart Healthcare pp 167–191Cite as

Interactions Between Genetics, Lifestyle, and Environmental Factors for Healthcare

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1005))

Abstract

The occurrence and progression of diseases are strongly associated with a combination of genetic, lifestyle, and environmental factors. Understanding the interplay between genetic and nongenetic components provides deep insights into disease pathogenesis and promotes personalized strategies for people healthcare. Recently, the paradigm of systems medicine, which integrates biomedical data and knowledge at multidimensional levels, is considered to be an optimal way for disease management and clinical decision-making in the era of precision medicine. In this chapter, epigenetic-mediated genetics-lifestyle-environment interactions within specific diseases and different ethnic groups are systematically discussed, and data sources, computational models, and translational platforms for systems medicine research are sequentially presented. Moreover, feasible suggestions on precision healthcare and healthy longevity are kindly proposed based on the comprehensive review of current studies.

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Acknowledgments

This study was supported by the National Natural Science Foundation of China (NSFC) (grant nos. 31670851, 31470821, and 91530320) and National Key R&D programs of China (2016YFC1306605).

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Authors and Affiliations

  1. Center for Systems Biology, Soochow University, No.1 Shizi Street, Suzhou, Jiangsu, 215006, China

    Yuxin Lin & Bairong Shen

  2. School of Chemistry, Biology and Materials Engineering, Suzhou University of Science and Technology, No.1 Kerui road, Suzhou, Jiangsu, 215011, China

    Jiajia Chen

  3. Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, Jiangsu, 215163, China

    Bairong Shen

  4. Medical College of Guizhou University, Guiyang, 550025, China

    Bairong Shen

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    Bairong Shen

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Lin, Y., Chen, J., Shen, B. (2017). Interactions Between Genetics, Lifestyle, and Environmental Factors for Healthcare. In: Shen, B. (eds) Translational Informatics in Smart Healthcare. Advances in Experimental Medicine and Biology, vol 1005. Springer, Singapore. https://doi.org/10.1007/978-981-10-5717-5_8

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