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Modeling the Alterations in Calcium Homeostasis in the Presence of Protein and VGCC for Alzheimeric Cell

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Book cover Soft Computing: Theories and Applications

Part of the book series: Advances in Intelligent Systems and Computing ((AISC,volume 584))

Abstract

Alzheimer’s disease is one of the neurodegenerative diseases which cannot be cured completely, but only the progression of it can be prevented. The causes of the Alzheimer’s are many, but the present piece of work focuses on the alterations taking place in the calcium homeostasis in the presence of protein, i.e., buffer and voltage gated calcium channel (VGCC). The fundamental nature of the buffer is to decrease the cytosolic calcium level, whereas the role of VGCC is to increase the same. Hence, the combination of both the parameters helps in maintaining the calcium concentration, thus preventing the cell loss in Alzheimer’s disease. On the basis of this, a two-dimensional mathematical model is developed using these parameters and is solved analytically using Laplace transform which is further simulated in MATLAB.

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Author information

Authors and Affiliations

  1. Department of Mathematics, School of Technology, Pandit Deendayal Petroleum University, Raisan, Gandhinagar, 382007, Gujarat, India

    Devanshi D. Dave & Brajesh Kumar Jha

Authors
  1. Devanshi D. Dave
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  2. Brajesh Kumar Jha
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Correspondence to Devanshi D. Dave .

Editor information

Editors and Affiliations

  1. Department of Applied Science and Engineering, IIT Roorkee, Saharanpur, India

    Millie Pant

  2. Department of Physics, Amity School of Applied Sciences, Amity University Rajasthan, Jaipur, Rajasthan, India

    Kanad Ray

  3. Department of Computer Science and Engineering, Amity School of Engineering and Technology, Amity University Rajasthan, Jaipur, Rajasthan, India

    Tarun K. Sharma

  4. Department of Electronics and Communication Engineering, SEEC, Manipal University Jaipur, Jaipur, Rajasthan, India

    Sanyog Rawat

  5. Surface Characterization Group, NIMS, Nano Characterization Unit, Advanced Key Technologies Division, Tsukuba, Ibaraki, Japan

    Anirban Bandyopadhyay

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Dave, D.D., Jha, B.K. (2018). Modeling the Alterations in Calcium Homeostasis in the Presence of Protein and VGCC for Alzheimeric Cell. In: Pant, M., Ray, K., Sharma, T., Rawat, S., Bandyopadhyay, A. (eds) Soft Computing: Theories and Applications. Advances in Intelligent Systems and Computing, vol 584. Springer, Singapore. https://doi.org/10.1007/978-981-10-5699-4_18

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  • DOI: https://doi.org/10.1007/978-981-10-5699-4_18

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-10-5698-7

  • Online ISBN: 978-981-10-5699-4

  • eBook Packages: EngineeringEngineering (R0)

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