Abstract
Children can be considered as a high-risk population to environmental stress since some of the organ systems including the immune system and respiratory system are still in development during childhood. During childhood, the impact of environmental pollutants exposure may program child growth and development that have long-term consequences on later health and disease risk. Considering the rapid economic growth in recent decades in China, the impact of ambient air pollution on children health causes concerns. Therefore, we aimed to review the current epidemiological evidence on the effects of air pollution exposure on adverse health outcome, including respiratory diseases, lung function, high blood pressure, cognitive disorder, and obesity in childhood in China. We believe that the findings summarized in our review demonstrate an unequivocal relationship between air pollutants exposure and Chinese children health and these results have large public health influences.
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References
Avol EL, Gauderman WJ, Tan SM, London SJ, Peters JM. Respiratory effects of relocating to areas of differing air pollution levels. Am J Resp Crit Care. 2001;164(11):2067–72.
Araujo JA. Particulate air pollution, systemic oxidative stress, inflammation, and atherosclerosis. Air Qual Atmos Health. 2011;4:79–93.
Bilenko N, Lv R, Brunekreef B, Beelen R, Eeftens M, Hoek G, Houthuijs D, de Jongste JC, Ev K, Koppelman GH, Meliefste K, Oldenwening M, Smit HA, Wijga AH, Gehring U. Traffic-related air pollution and noise and children’s blood pressure: results from the PIAMA birth cohort study. Eur J Prev Cardiol. 2015;22:4–12.
Brook RD, Rajagopalan S. Particulate matter, air pollution, and blood pressure. J Am Soc Hypertens. 2009;3:332–50.
Brook RD, Urch B, Dvonch JT, Bard RL, Speck M, Keeler G, Morishita M, Marsik FJ, Kamal AS, Kaciroti N, Harkema J, Corey P, Silverman F, Gold DR, Wellenius G, Mittleman MA, Rajagopalan S, Brook JR. Insights into the mechanisms and mediators of the effects of air pollution exposure on blood pressure and vascular function in healthy humans. Hypertension.2009;54:659-67.
Brook RD, Rajagopalan S, Pope CA, Brook JR, Bhatnagar A, Diez-Roux AV, Holguin F, Hong Y, Luepker RV, Mittleman MA, Peters A, Siscovick D, Smith SC, Whitsel L, Kaufman JD, Epidemiology obotAHACo, Prevention CotKiCD, Council on Nutrition PA, Metabolism. Particulate matter air pollution and cardiovascular disease: an update to the scientific statement from the American Heart Association. Circulation. 2010;121:2331–78.
Calderon-Garciduenas L, Azzarelli B, Acuna H, Garcia R, Gambling T, Osnaya N, Monroy S, DEL Tizapanitzi M, Carson J, Villarreal-Calderon A, Rewcastle B. Air Pollution and Brain Damage. Toxicol Pathol 2002;30(3):373–89.
Calderón-Garcidueñas L, Vincent R, Mora-Tiscareño A, Franco-Lira M, Henríquez-Roldán C, Barragán-Mejía G, Garrido-García L, Camacho-Reyes L, Valencia-Salazar G, Paredes R, Romero L, Osnaya H, Villarreal-Calderón R, Torres-Jardón R, Hazucha MJ, Reed W. Elevated plasma endothelin-1 and pulmonary arterial pressure in children exposed to air pollution. Environ Health Perspect. 2007;115:1248–53.
Chan CK, Yao X. Air pollution in mega cities in China. Atmos Environ. 2008;42(1):1–42.
Chang YK, Wu CC, Lee LT, Lin RS, Yu YH, Chen YC. The short-term effects of air pollution on adolescent lung function in Taiwan. Chemosphere. 2012;87(1):26–30.
Chen CH, Chan CC, Chen BY, Cheng TJ, Guo YL. Effects of particulate air pollution and ozone on lung function in non-asthmatic children. Environ Res. 2015;137:40–8.
Chuang GC, Yang Z, Westbrook DG, Pompilius M, Ballinger CA, White CR, Krzywanski DM, Postlethwait EM, Ballinger SW. Pulmonary ozone exposure induces vascular dysfunction, mitochondrial damage, and atherogenesis. Am J Phys Lung Cell Mol Phys. 2009;297:L209–16.
Dinh QN, Drummond GR, Sobey CG, Chrissobolis S. Roles of inflammation, oxidative stress, and vascular dysfunction in hypertension. Biomed Res Int. 2014;2014:406960.
Dodd JW, Getov SV, Jones PW. Cognitive function in COPD. Eur Respir J. 2010;35:913–22.
Dong GH, Chen T, Liu MM, Wang D, Ma YN, Ren WH, Lee YL, Zhao YD, He QC. Gender differences and effect of air pollution on asthma in children with and without allergic predisposition: northeast chinese children health study. PLoS One. 2011;6:e22470.
Dong G-H, Qian Z, Liu M-M, Wang D, Ren W-H, Flick LH, Fu J, Wang J, Chen W, Simckes M, Trevathan E. Ambient air pollution and the prevalence of obesity in chinese children: the seven northeastern cities study. Obesity. 2014;22:795–800.
Dong GH, Qian Z, Liu MM, Wang D, Ren WH, Fu Q, Wang J, Simckes M, Ferguson TF, Trevathan E. Obesity enhanced respiratory health effects of ambient air pollution in Chinese children: the seven northeastern cities study. Int J Obes. 2013;37:94–100.
Dong G-H, Qian Z, Trevathan E, Zeng X-W, Vaughn MG, Wang J, Zhao Y, Liu Y-Q, Ren W-H, Qin X-D. Air pollution associated hypertension and increased blood pressure may be reduced by breastfeeding in Chinese children: the seven northeastern cities chinese children’s study. Int J Cardiol. 2014;176:956–61.
Dong G-H, Wang J, Zeng X-W, Chen L, Qin X-D, Zhou Y, Li M, Yang M, Zhao Y, Ren W-H, Hu Q-S. Interactions between air pollution and obesity on blood pressure and hypertension in Chinese children. Epidemiology. 2015;26:740–7.
Elder A, Gelein R, Silva V, Feikert T, Opanashuk L, Carter J, Potter R, Maynard A, Ito Y, Finkelstein J, Oberdörster G. Translocation of inhaled ultrafine manganese oxide particles to the central nervous system. Environ Health Perspect. 2006;114(8):1172–8.
Freire C, Ramos R, Puertas R, Lopez-Espinosa MJ, Julvez J, Aguilera I, Cruz F, Fernandez MF, Sunyer J, Olea N. Association of traffic-related air pollution with cognitive development in children. J Epidemiol Community Heath. 2010;64(3):223–8.
Gaffney AW, Hang JQ, Lee MS, Su L, Zhang FY, Christiani DC. Socioeconomic status is associated with reduced lung function in China: an analysis from a large cross-sectional study in Shanghai. BMC Public Health. 2016;16:96.
Gao Y, Chan EYY, Li LP, He QQ, Wong TW. Chronic effects of ambient air pollution on lung function among Chinese children. Arch Dis Child. 2013;98(2):128–35.
Gao Y, Chan EY, Li L, Lau PW, Wong TW. Chronic effects of ambient air pollution on respiratory morbidities among Chinese children: a cross-sectional study in Hong Kong. BMC Public Health. 2014;14:105.
Gauderman WJ, Avol E, Gilliland F, Vora H, Thomas D, Berhane K, McConnell R, Kuenzli N, Lurmann F, Rappaport E, Margolis H, Bates D, Peters J. The effect of air pollution on lung development from 10 to 18 years of age. New Engl J Med. 2004;351(11):1057–67.
Giorgini P, Di Giosia P, Grassi D, Rubenfire M, Brook RD, Ferri C. Air pollution exposure and blood pressure: an updated review of the literature. Curr Pharm Des. 2016;22:28–51.
Haberzettl P, O’Toole TE, Bhatnagar A, Conklin DJ. Exposure to fine particulate air pollution causes vascular insulin resistance by inducing pulmonary oxidative stress. Environ Health Perspect. 2016;124:1830–9.
Hegewald MJ, Crapo RO. Socioeconomic status and lung function. Chest. 2007;132(5):1608–14.
Horak F, Studnicka M, Gartner C, Spengler JD, Tauber E, Urbanek R, Veiter A, Frischer T. Particulate matter and lung function growth in children: a 3-yr follow-up study in Austrian schoolchildren. Eur Respir J. 2002;19(5):838–45.
Hua J, Yin Y, Peng L, Du L, Geng F, Zhu L. Acute effects of black carbon and PM2.5 on children asthma admissions: a time-series study in a chinese city. Sci Total Environ. 2014;481:433–8.
Hwang BF, Chen YH, Lin YT, Wu XT, Lee YL. Relationship between exposure to fine particulates and ozone and reduced lung function in children. Environ Res. 2015;137:382–90.
Ino T. Maternal smoking during pregnancy and offspring obesity: meta-analysis. Pediatr Int. 2010;52:94–9.
Jerrett M, McConnell R, Chang CCR, Wolch J, Reynolds K, Lurmann F, Gilliland F, Berhane K. Automobile traffic around the home and attained body mass index: a longitudinal cohort study of children aged 10–18 years. Prev Med. 2010;(50, Supplement):S50–8.
Jerrett M, McConnell R, Wolch J, Chang R, Lam C, Dunton G, Gilliland F, Lurmann F, Islam T, Berhane K. Traffic-related air pollution and obesity formation in children: a longitudinal, multilevel analysis. Environ Health. 2014;13:49.
Jirásek JE. An atlas of human prenatal developmental mechanics: anatomy and staging. London: CRC Press; 2004.
Joshi S, Kotecha S. Lung growth and development. Early Hum Dev. 2007;83:789–94.
Kajekar R. Environmental factors and developmental outcomes in the lung. Pharmacol Ther. 2007;114:129–45.
Kasamatsu J, Shima M, Yamazaki S, Tamura K, Sun GF. Effects of winter air pollution on pulmonary function of school children in Shenyang China. Int J Hyg Environ Health. 2006;209(5):435–44.
Kleinman MT, Araujo JA, Nel A, Sioutas C, Campbell A, Cong PQ, Lia H, Bondy SC. Inhaled ultrafine particulate matter affects CNS inflammatory processes and may act via MAP kinase signaling pathways. Toxicol Lett. 2008;178(2):127–30.
Lauer RM, Burns TL, Clarke WR, Mahoney LT. Childhood predictors of future blood pressure. Hypertension. 1991;18:I74.
Lee YL, Wang WH, Lu CW, Lin YH, Hwang BF. Effects of ambient air pollution on pulmonary function among schoolchildren. Int J Hyg Environ Health. 2011;214(5):369–75.
Lewington S, Li L, Sherliker P, Guo Y, Millwood I, Bian Z, Whitlock G, Yang L, Collins R, Chen J, Wu X, Wang S, Hu Y, Jiang L, Yang L, Lacey B, Peto R, Chen Z. Seasonal variation in blood pressure and its relationship with outdoor temperature in 10 diverse regions of China: the China Kadoorie Biobank. J Hypertens. 2012;30:1383–91.
Li Q, Guo Y, Wei D-M, Song Y, Song J-Y, Ma J, Wang H-J. Does local ambient temperature impact children’s blood pressure? A Chinese National Survey. Environ Health. 2016;15:21.
Liu C, Fuertes E, Tiesler CMT, Birk M, Babisch W, Bauer C-P, Koletzko S, von Berg A, Hoffmann B, Heinrich J. The associations between traffic-related air pollution and noise with blood pressure in children: results from the GINIplus and LISAplus studies. Int J Hyg Environ Health. 2014;217:499–505.
Lin G, Fu JY, Jiang D, Hu WS, Dong DL, Huang YH, Zhao MD. Spatio-temporal variation of PM2.5 concentrations and their relationship with geographic and socioeconomic factors in China. Int J Environ Res Public Health. 2014;11(1):173–86.
Liang Y-J, Xi B, Song A-Q, Liu J-X, Mi J. Trends in general and abdominal obesity among Chinese children and adolescents 1993–2009. Pediatr Obes. 2012;7:355–64.
Lin W, Huang W, Zhu T, Hu M, Brunekreef B, Zhang Y, Liu X, Cheng H, Gehring U, Li C, Tang X. Acute respiratory inflammation in children and black carbon in ambient air before and during the 2008 beijing olympics. Environ Health Perspect. 2011;119:1507–12.
Lin W, Brunekreef B, Gehring U. Meta-analysis of the effects of indoor nitrogen dioxide and gas cooking on asthma and wheeze in children. Int J Epidemiol. 2013;42:1724–37.
Liu F, Zhao Y, Liu YQ, Liu Y, Sun J, Huang MM, Liu Y, Dong GH. Asthma and asthma related symptoms in 23,326 chinese children in relation to indoor and outdoor environmental factors: the seven northeastern cities (snec) study. Sci Total Environ. 2014;497–498:10–7.
Liu JH, Lewis G. Environmental toxicity and poor cognitive outcomes in children and adults. J Environ Health. 2014;76(6):130–8.
Liu L, Zhang JL. Ambient air pollution and children’s lung function in China. Environ Int. 2009;35:178–86.
Lucchini R, Dorman D, Elder A, Veronesi B. Neurological impacts from inhalation of pollutants and nose-brain connection. Neurotoxicology. 2012;33(4):838–41.
Madaniyazi L, Guo YM, Ye XF, Kim D, Zhang YX, Pan XC. Effects of airborne metals on lung function in inner Mongolian schoolchildren. J Occup Environ Med. 2013;55(1):92–8.
Mao G, Nachman R, Sun Q, Zhang X, Koehler K, Chen Z, XH, Wang G, Caruso D, Zong G, Pearson C, Ji H, Biswa S, Zuckerman B, Wills-Karp M, Wang X. Individual and joint effects of early-life ambient PM2.5 exposure and maternal pre-pregnancy obesity on childhood overweight or obesity. Environ Health Perspect. 2016.; Sep 16. [Epub ahead of print]; doi:10.1289/EHP261.
Martin RM, Ness AR, Gunnell D, Emmett P, Smith GD. Does breast-feeding in infancy lower blood pressure in childhood? Avon Longitudinal Study Parents Child (ALSPAC). 2004;109:1259–66.
McConnell R, Shen E, Gilliland FD, Jerrett M, Wolch J, Chang C-C, Lurmann F, Berhane K. A longitudinal cohort study of body mass index and childhood exposure to secondhand tobacco smoke and air pollution: the Southern California Children’s Health Study. Environ Health Perspect. 2015;123:360–6.
Mustafić H, Jabre P, Caussin C, Murad MH, Escolano S, Tafflet M, Périer MC, Marijon E, Vernerey D, Empana JP, Jouven X. Main air pollutants and myocardial infarction: a systematic review and meta-analysis. JAMA. 2012;307:713–21.
National Bureau of Statistics of China. China statistical yearbook: population by age and sex. Beijing: National Bureau of Statistics; 2014.
Ng M, Fleming T, Robinson M, Thomson B, Graetz N, Margono C, Mullany EC, Biryukov S, Abbafati C, Abera SF, Abraham JP, Abu-Rmeileh NME, Achoki T, AlBuhairan FS, Alemu ZA, Alfonso R, Ali MK, Ali R, Guzman NA, Ammar W, Anwari P, Banerjee A, Barquera S, Basu S, Bennett DA, Bhutta Z, Blore J, Cabral N, Nonato IC, Chang J-C, Chowdhury R, Courville KJ, Criqui MH, Cundiff DK, Dabhadkar KC, Dandona L, Davis A, Dayama A, Dharmaratne SD, Ding EL, Durrani AM, Esteghamati A, Farzadfar F, Fay DFJ, Feigin VL, Flaxman A, Forouzanfar MH, Goto A, Green MA, Gupta R, Hafezi-Nejad N, Hankey GJ, Harewood HC, Havmoeller R, Hay S, Hernandez L, Husseini A, Idrisov BT, Ikeda N, Islami F, Jahangir E, Jassal SK, Jee SH, Jeffreys M, Jonas JB, Kabagambe EK, Khalifa SEAH, Kengne AP, Khader YS, Khang Y-H, Kim D, Kimokoti RW, Kinge JM, Kokubo Y, Kosen S, Kwan G, Lai T, Leinsalu M, Li Y, Liang X, Liu S, Logroscino G, Lotufo PA, Lu Y, Ma J, Mainoo NK, Mensah GA, Merriman TR, Mokdad AH, Moschandreas J, Naghavi M, Naheed A, Nand D, Narayan KMV, Nelson EL, Neuhouser ML, Nisar MI, Ohkubo T, Oti SO, Pedroza A, Prabhakaran D, Roy N, Sampson U, Seo H, Sepanlou SG, Shibuya K, Shiri R, Shiue I, Singh GM, Singh JA, Skirbekk V, Stapelberg NJC, Sturua L, Sykes BL, Tobias M, Tran BX, Trasande L, Toyoshima H, van de Vijver S, Vasankari TJ, Veerman JL, Velasquez-Melendez G, Vlassov VV, Vollset SE, Vos T, Wang C, Wang X, Weiderpass E, Werdecker A, Wright JL, Yang YC, Yatsuya H, Yoon J, Yoon S-J, Zhao Y, Zhou M, Zhu S, Lopez AD, Murray CJL, Gakidou E. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study. Lancet. 2013. 2014;384:766–81.
Pan G, Zhang S, Feng Y, Takahashi K, Kagawa J, Yu L, Wang P, Liu M, Liu Q, Hou S, Pan B, Li J. Air pollution and children’s respiratory symptoms in six cities of Northern China. Respir Med. 2010;104:1903–11.
Perera FP, Rauh V, Whyatt RM, Tsai WY, Tang D, Diaz D, Hoepner L, Barr D, Tu YH, Camann D, Kinney P. Effect of prenatal exposure to airborne polycyclic aromatic hydrocarbons on neurodevelopment in the first 3 years of life among inner-city children. Environ Health Perspect. 2006;114(8):1287–92.
Perera F, Li TY, Lin C, Tang D. Effects of prenatal polycyclic aromatic hydrocarbon exposure and environmental tobacco smoke on child IQ in a Chinese cohort. Environ Res. 2012;114:40–6.
Perez CM, Hazari MS, Farraj AK. Role of autonomic reflex arcs in cardiovascular responses to air pollution exposure. Cardiovasc Toxicol. 2015;15:69–78.
Pieters N, Koppen G, Van Poppel M, De Prins S, Cox B, Dons E, Nelen V, Panis LI, Plusquin M, Schoeters G, Nawrot TS. Blood pressure and same-day exposure to air pollution at school: associations with nano-sized to coarse PM in children. Environ Health Perspect. 2015;123:737–42.
Pope CA, Dockery DW. Health effects of fine particulate air pollution: lines that connect. J Air Waste Manag Assoc. 2006;56:709–42.
Rojas-Martinez R, Perez-Padilla R, Olaiz-Fernandez G, Mendoza-Alvarado L, Moreno-Macias H, Fortoul T, McDonnell W, Loomis D, Romieu I. Lung function growth in children with long-term exposure to air pollutants in Mexico City. Am J Resp Crit Care. 2007;176(4):377–84.
Roy A, Hu W, Wei FS, Korn L, Chapman RS, Zhang JF. Ambient particulate matter and lung function growth in Chinese children. Epidemiology. 2012;23(3):464–72.
Schmid O, Möller W, Semmler-Behnke M, Ferron GA, Karg E, Lipka J, Schulz H, Kreyling WG, Stoeger T. Dosimetry and toxicology of inhaled ultrafine particles. Biomarkers. 2009;14:67–73.
Seaton A, Godden D, MacNee W, Donaldson K. Particulate air pollution and acute health effects. Lancet. 1995;345:176–8.
Sin DD, Wu LL, Man SFP. The relationship between reduced lung function and cardiovascular mortality – a population-based study and a systematic review of the literature. Chest. 2005;127(6):1952–9.
Sughis M, Nawrot TS, Ihsan-ul-Haque S, Amjad A, Nemery B. Blood pressure and particulate air pollution in schoolchildren of Lahore, Pakistan. BMC Public Health. 2012;12:1–8.
Suglia SF, Gryparis A, Wright RO, Schwartz J, Wright RJ. Association of black carbon with cognition among children in a prospective birth cohort study. Am J Epidemiol. 2008;167(3):280–6.
Sun Q, Yue P, Deiuliis JA, Lumeng CN, Kampfrath T, Mikolaj MB, Cai Y, Ostrowski MC, Lu B, Parthasarathy S, Brook RD, Moffatt-Bruce SD, Chen LC, Rajagopalan S. Ambient air pollution exaggerates adipose inflammation and insulin resistance in a mouse model of diet-induced obesity. Circulation. 2009;119(119):538–46.
Wang S, Zhang J, Zeng X, Zeng Y, Wang S, Chen S. Association of traffic-related air pollution with children’s neurobehavioral functions in Quanzhou, China. Environ Health Perspect. 2009;117:1612–8.
Wei Y, Zhang J, Li Z, Gow A, Chung KF, Hu M, Sun Z, Zeng L, Zhu T, Jia G, Li X, Duarte M, Tang X. Chronic exposure to air pollution particles increases the risk of obesity and metabolic syndrome: findings from a natural experiment in Beijing. FASEB J. 2016;30:2115–22.
World Health Organization. Effects of air pollution on children’s health and development – a review of the evidence. Copenhagen: WHO Regional Office for Europe; 2005.
World Health Organization. Burden of disease from household air pollution for 2012: summary of results; 2014. Accessed 20 July 2016.
World Health Organization. Ambient air pollution: a global assessment of exposure and burden of disease. Geneva: WHO Document Production Services; 2016.
Xu X, Yavar Z, Verdin M, Ying Z, Mihai G, Kampfrath T, Wang A, Zhong M, Lippmann M, Chen L-C, Rajagopalan S, Sun Q. Effect of early particulate air pollution exposure on obesity in mice: role of p47phox. Arterioscler Thromb Vasc Biol. 2010;30:2518–27.
Zeng X-W, Qian Z, Vaughn MG, Nelson EJ, Dharmage SC, Bowatte G, Perret J, Chen D-H, Ma H, Lin S, de Foy B, Hu L-W, Yang B-Y, Xu S-L, Zhang C, Tian Y-P, Nian M, Wang J, Xiao X, Bao W-W, Zhang Y-Z, Dong G-H. Positive association between short-term ambient air pollution exposure and children blood pressure in China–result from the Seven Northeast Cities (SNEC) study. Environ Pollut. 2017;224:698–705.
Zeng XW, Vivian E, Mohammed K, Jakhar S, Vaughn M, Huang J, Zelicoff A, Xaverius P, Bai ZP, Lin S, Hao YT, Paul G, Morawska L, Wang SQ, Qian ZM, Dong GH. Long-term ambient air pollution and lung function impairment in Chinese children from a high air pollution range area: the Seven Northeastern Cities (SNEC) study. Atmos Environ. 2016;138:144–51.
Zhao Z, Zhang Z, Wang Z, Ferm M, Liang Y, Norback D. Asthmatic symptoms among pupils in relation to winter indoor and outdoor air pollution in schools in Taiyuan, China. Environ Health Perspect. 2008;116:90–7.
Zou M-H. Is NAD(P)H oxidase a missing link for air pollution-enhanced obesity? Arterioscler Thromb Vasc Biol. 2010;30:2323–4.
Acknowledgments
This study was funded by grants from the Major Program of National Natural Science Foundation of China (91543208), the National Natural Science Foundation of China (No. 81472936, 81673127, 81673128, and 41501540), the National Natural Science Foundation of China - Guangdong Joint Fund Project (No. U1301234), the National Key Research and Development Program of China (2016YFC0207000), the Guangdong Province Natural Science Foundation (2014A050503027, and 2016A030313194), and the Fundamental Research Funds for the Central Universities (No. 16ykzd02, 16ykpy18, and 17ykpy16).
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Lin, WW., Chen, ZX., Kong, ML., Xie, YQ., Zeng, XW. (2017). Air Pollution and Children’s Health in Chinese. In: Dong, GH. (eds) Ambient Air Pollution and Health Impact in China. Advances in Experimental Medicine and Biology, vol 1017. Springer, Singapore. https://doi.org/10.1007/978-981-10-5657-4_7
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