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Similarities and Differences in Genetics

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Substance and Non-substance Addiction

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1010))

Abstract

Similar symptomatology manifestations and high co-morbidity in substance and non-substance addictions suggest that there may be a common pathogenesis between them. Associated with impulse control and emotional processing, the monoamine neurotransmitter system genes are suggested to be related to both substance and non-substance addictions, such as dopamine (DA) system, 5-hydroxytryptamine/serotonin (5-HT) system, the endogenous opioid system and so on. Here we reviewed the similarities and differences in genetics between classic substance addiction and common types of non-substance addiction, e.g. pathological gambling, Internet addiction, binge-eating disorder etc. It is necessary to systematically compare genetic mechanisms of non-substance addiction and substance addiction, which could reveal similarities and differences of substance addiction and non-addictive substances essentially, enhance our understanding of addiction theory and improve clinical practice with research results.

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Authors and Affiliations

  1. Department of Pharmacology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100191, China

    Yang Zhang & Jie Liang

  2. National Institute on Drug Dependence, Peking University, No. 38, Xueyuan Road, Haidian District, Beijing, 100191, China

    Yang Zhang, Yan Sun, Jie Liang & Jie Shi

  3. Institute of Mental Health/Peking University Sixth Hospital and National Clinical Research Center for Mental Disorders & Key Laboratory of Mental Health, Peking University, Beijing, 100191, China

    Lin Lu

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  1. Yang Zhang
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  2. Yan Sun
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  3. Jie Liang
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  4. Lin Lu
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Correspondence to Jie Shi .

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Editors and Affiliations

  1. Key Laboratory of Brain Function and Disease, Chinese Academy of Sciences, and School of Life Sciences, University of Science & Technology of China, Hefei, Anhui, China

    Xiaochu Zhang

  2. National Institute on Drug Dependence, Peking University, Beijing, China

    Jie Shi

  3. Department of Psychological Medicine, PLA Army General Hospital, Beijing, China

    Ran Tao

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Zhang, Y., Sun, Y., Liang, J., Lu, L., Shi, J. (2017). Similarities and Differences in Genetics. In: Zhang, X., Shi, J., Tao, R. (eds) Substance and Non-substance Addiction. Advances in Experimental Medicine and Biology, vol 1010. Springer, Singapore. https://doi.org/10.1007/978-981-10-5562-1_4

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