Etiopathology of Atopic Dermatitis: Immunological Aspects of Dendritic Cells (DCs) and Innate Lymphoid Cells (ILCs)

  • Saeko Nakajima
  • Tetsuya Honda
  • Kenji KabashimaEmail author


Dendritic cells (DCs) form a heterogeneous group of antigen-presenting cells that play different roles in skin immunology. Recent studies have revealed the existence of distinct DC populations in the skin, highlighting the complexity of the cutaneous DC network in the steady state and inflammatory conditions.

Recently, another new skin immune cell subset, innate lymphoid cells (ILCs), which are part of a heterogeneous family of innate immune cells, has emerged as an important contributor to inflammatory skin diseases, such as atopic dermatitis (AD) and psoriasis.

In this review, we will summarize the current understanding of the functions of cutaneous DCs and ILCs in the pathogenesis of AD and will discuss the potential implications of their functions in AD.


Langerhans cells (LCs) Dendritic cells (DCs) Type 2 innate lymphoid cells (ILC2s) 



This work was supported in part by Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology and the Ministry of Health, Labor, and Welfare of Japan.


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Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Saeko Nakajima
    • 1
  • Tetsuya Honda
    • 1
  • Kenji Kabashima
    • 1
    Email author
  1. 1.Department of DermatologyKyoto University Graduate School of MedicineKyotoJapan

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