Impairment of Productivity in the Workplace/Classroom in Japanese Patients with Atopic Dermatitis

  • Hiroyuki MurotaEmail author
  • Ichiro Katayama


The burden of medical costs and impaired work productivity in patients with allergic diseases requires attention. The vicious cycle between the rise in medical expenses and decreased work productivity has a socioeconomic impact. Evaluation of work productivity has been conducted in Japanese patients with allergic diseases, and impaired productivity in workplace/classroom and decreased daily activity have been observed. The burdens of these factors can be improved by proper treatment. Thus, evaluation of work productivity could be an important endpoint to decide the efficacy of treatment provided. This chapter summarizes the characteristics of Japanese patients with allergic diseases and estimates the burden of medical costs to Japanese patients.


Atopic dermatitis Quality of life Work productivity Activity impairment Questionnaire Classroom productivity Sedative antihistamine 


  1. 1.
    Bunn WB 3rd, Pikelny DB, Paralkar S, et al. The burden of allergies--and the capacity of medications to reduce this burden-in a heavy manufacturing environment. J Occup Environ Med. 2003;45:941–55.CrossRefPubMedGoogle Scholar
  2. 2.
    Carr WW, Nelson MR, Hadley JA. Managing rhinitis: strategies for improved patient outcomes. Allergy Asthma Proc. 2008;29:349–57.CrossRefPubMedGoogle Scholar
  3. 3.
    Guyatt GH, Feeny DH, Patrick DL. Measuring health-related quality of life. Ann Intern Med. 1993;118:622–9.CrossRefPubMedGoogle Scholar
  4. 4.
    Cabinet office GoJ. Regional economy. 2015.
  5. 5.
    Goetzel RZ, Long SR, Ozminkowski RJ, et al. Health, absence, disability, and presenteeism cost estimates of certain physical and mental health conditions affecting U.S. employers. J Occup Environ Med. 2004;46:398–412.CrossRefPubMedGoogle Scholar
  6. 6.
    Zuberbier T, Lotvall J, Simoens S, et al. Economic burden of inadequate management of allergic diseases in the European Union: a GA(2) LEN review. Allergy. 2014;69:1275–9.CrossRefPubMedGoogle Scholar
  7. 7.
    Szeinbach SL, Seoane-Vazquez EC, Beyer A, et al. The impact of allergic rhinitis on work productivity. Prim Care Respir J. 2007;16:98–105.CrossRefPubMedGoogle Scholar
  8. 8.
    Lamb CE, Ratner PH, Johnson CE, et al. Economic impact of workplace productivity losses due to allergic rhinitis compared with select medical conditions in the United States from an employer perspective. Curr Med Res Opin. 2006;22:1203–10.CrossRefPubMedGoogle Scholar
  9. 9.
    Thompson AK, Finn AF, Schoenwetter WF. Effect of 60 mg twice-daily fexofenadine HCl on quality of life, work and classroom productivity, and regular activity in patients with chronic idiopathic urticaria. J Am Acad Dermatol. 2000;43:24–30.CrossRefPubMedGoogle Scholar
  10. 10.
    Murota H, Kitaba S, Tani M, et al. Effects of nonsedative antihistamines on productivity of patients with pruritic skin diseases. Allergy. 2009;65(7):929–30. doi: 10.1111/j.398-9995.2009.02262.x.CrossRefPubMedGoogle Scholar
  11. 11.
    Murota H, Kitaba S, Tani M, et al. Impact of sedative and non-sedative antihistamines on the impaired productivity and quality of life in patients with pruritic skin diseases. Allergol Int. 2010;59:345–54.CrossRefPubMedGoogle Scholar
  12. 12.
    Reilly MC, Zbrozek AS, Dukes EM. The validity and reproducibility of a work productivity and activity impairment instrument. Pharmacoeconomics. 1993;4:353–65.CrossRefPubMedGoogle Scholar
  13. 13.
    Reilly MC, Tanner A, Meltzer EO. Work, classroom and activity impairment instruments: validation studies in allergic rhinitis. Clin Drug Investig. 1996;11:278–88.CrossRefGoogle Scholar
  14. 14.
    Reilly MC, Lavin PT, Kahler KH, et al. Validation of the dermatology life quality index and the work productivity and activity impairment-chronic hand dermatitis questionnaire in chronic hand dermatitis. J Am Acad Dermatol. 2003;48:128–30.CrossRefPubMedGoogle Scholar
  15. 15.
    Okubo K, Gotoh M, Shimada K, et al. Fexofenadine improves the quality of life and work productivity in Japanese patients with seasonal allergic rhinitis during the peak cedar pollinosis season. Int Arch Allergy Immunol. 2005;136:148–54.CrossRefPubMedGoogle Scholar
  16. 16.
    Hide M, Hiragun T, Japanese DA. Japanese guidelines for diagnosis and treatment of urticaria in comparison with other countries. Allergol Int. 2012;61:517–27.CrossRefPubMedGoogle Scholar
  17. 17.
    Pearce DJ, Singh S, Balkrishnan R, et al. The negative impact of psoriasis on the workplace. J Dermatolog Treat. 2006;17:24–8.CrossRefPubMedGoogle Scholar
  18. 18.
    Amatya B, Wennersten G, Nordlind K. Patients’ perspective of pruritus in chronic plaque psoriasis: a questionnaire-based study. J Eur Acad Dermatol Venereol. 2008;22:822–6.CrossRefPubMedGoogle Scholar
  19. 19.
    Fowler JF, Ghosh A, Sung J, et al. Impact of chronic hand dermatitis on quality of life, work productivity, activity impairment, and medical costs. J Am Acad Dermatol. 2006;54:448–57.CrossRefPubMedGoogle Scholar
  20. 20.
    Yano C, Saeki H, Ishiji T, et al. Impact of disease severity on work productivity and activity impairment in Japanese patients with atopic dermatitis. J Dermatol. 2013;40:736–9.CrossRefPubMedGoogle Scholar
  21. 21.
    Murota H, Katayama I. Exacerbating factors of itch in atopic dermatitis. Allergol Int. 2016;63:377.Google Scholar
  22. 22.
    Lavery MJ, Stull C, Nattkemper LA, et al. Nocturnal pruritus: prevalence, characteristics and impact on ItchyQoL in a chronic itch population. Acta Derm Venereol. 2016;97(4):513–5.CrossRefGoogle Scholar
  23. 23.
    Goetzel RZ, Ozminkowski RJ, Long SR. Development and reliability analysis of the Work Productivity Short Inventory (WPSI) instrument measuring employee health and productivity. J Occup Environ Med. 2003;45:743–62.CrossRefPubMedGoogle Scholar
  24. 24.
    Lerner D, Amick BC 3rd, Rogers WH, et al. The work limitations questionnaire. Med Care. 2001;39:72–85.CrossRefPubMedGoogle Scholar
  25. 25.
    Kessler RC, Barber C, Beck A, et al. The World Health Organization health and work performance questionnaire (HPQ). J Occup Environ Med. 2003;45:156–74.CrossRefPubMedGoogle Scholar
  26. 26.
    Koopman C, Pelletier KR, Murray JF, et al. Stanford presenteeism scale: health status and employee productivity. J Occup Environ Med. 2002;44:14–20.CrossRefPubMedGoogle Scholar
  27. 27.
    Endicott J, Nee J. Endicott Work Productivity Scale (EWPS): a new measure to assess treatment effects. Psychopharmacol Bull. 1997;33:13–6.PubMedGoogle Scholar
  28. 28.
    van Roijen L, Essink-Bot ML, Koopmanschap MA, et al. Labor and health status in economic evaluation of health care. The health and labor questionnaire. Int J Technol Assess Health Care. 1996;12:405–15.CrossRefPubMedGoogle Scholar
  29. 29.
    A new tool to measure the relationship between health-related quality of life and workforce productivity.Google Scholar
  30. 30.
    Jenkinson C, Coulter A, Wright L. Short form 36 (SF36) health survey questionnaire: normative data for adults of working age. BMJ. 1993;306:1437–40.CrossRefPubMedPubMedCentralGoogle Scholar
  31. 31.
    Lynch W, Riedel J, Institute for Health and Productivity Management. Measuring employee productivity. A guide to self-assessment tools. Denver, CO: William Mercer Inc.; 2001.Google Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  1. 1.Department of DermatologyOsaka UniversityOsakaJapan

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