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Skin Care and Intervention

  • Yukihiro OhyaEmail author
Chapter

Abstract

Atopic dermatitis (AD) is a chronic inflammatory skin disorder and also recognized as one of the allergic diseases that has increased within a half century when rapid environmental and lifestyle changes have occurred as a background. Most randomized controlled trials (RCTs) for high-risk infants with an intention of allergen elimination failed to prevent the onset of AD. Although some RCTs that administered probiotics during both prenatal and postnatal periods showed preventive effects on AD, a meta-analysis showed that probiotics were not effective as a viable treatment of established AD. Now, skin barrier dysfunction is recognized as a key initiator to progress AD, and the hypothesis that improving the properties of skin barrier early in life by applying emollients might prevent or delay the onset of AD was verified by two independent RCTs. One was a multicenter RCT carried out in the United States (USA) and United Kingdom (UK) applying emollients from birth to 6 months resulting in 50% reduction of the onset of AD. The other was a single-center RCT carried out in Japan applying an emollient from birth to 8 months resulting in 34% reduction of the onset. Skin care seems to be important not only for the prevention and treatment of AD but also for prevention of food allergy and other allergic diseases. In the future, larger-scale RCTs are expected to confirm preventive effect of skin care with emollients on AD and other allergic diseases in later life.

Keywords

Emollients Food allergy Prevention RCT Skin care 

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Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  1. 1.Division of Allergy, Department of Medical SubspecialtiesNational Center for Child Health and DevelopmentTokyoJapan

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