Drug Therapy: Systemic

  • Norito KatohEmail author


Systemic therapy is indicated for patients with severe atopic dermatitis (AD) who do not respond to adequate topical treatment or who cannot continue to receive topical therapy due to its side effects, such as skin atrophy. Before administering systemic immunosuppressive or immunomodulatory pharmaceuticals, clinicians should check whether the diagnosis of AD is correct, consider possible differential diagnoses, and examine whether the patient’s adherence to topical treatments is sufficient. The currently available immunosuppressive and immunomodulatory drugs mainly produce their anti-inflammatory effects by suppressing the proliferation and functions of lymphocytes. However, since they can cause a range of adverse effects, strict monitoring before and during treatment is mandatory. Patient education regarding the possible adverse effects of treatment, the pathogenesis of AD, and the practical measures for treating AD is very important.


Cyclosporine Azathioprine Mycophenolic acid Methotrexate Antihistamine 


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© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  1. 1.Department of Dermatology, Graduate School of Medical ScienceKyoto Prefectural University of MedicineKyotoJapan

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