Management: Drug Therapy—Ointment
Atopic dermatitis (AD) is an allergic inflammatory skin disease etiologically associated with disrupted skin barrier function. Topical treatment is a fundamental approach for the management of AD. This includes various kinds of emollients/moisturizers as skin care and anti-inflammatory drugs, such as corticosteroids and tacrolimus. Improvement of barrier function could lead to reduced risk for the development and/or exacerbation of AD and reduces the chance for epicutaneous sensitization against environmental allergens, which may induce systemic allergy. Anti-inflammatory drugs are used for controlling flare-up of skin inflammation during the course of the disease. Proactive therapy, comprising continuous or periodical use and gradual tapering of anti-inflammatory drugs with emollients/moisturizers even when clinical symptoms improve, has been found to be useful for obtaining long-term remission. Patient adherence to external application is essential for reaching successful treatment outcomes with topical drugs.
KeywordsBarrier function Corticosteroids Proactive therapy Tacrolimus
- 6.Fukuie T, Hirakawa S, Narita M, Nomura I, Matsumoto K, Tokura Y, et al. Potential preventive effects of proactive therapy on sensitization in moderate to severe childhood atopic dermatitis: a randomized, investigator-blinded, controlled study. J Dermatol. 2016;43:1283–92. doi: 10.1111/1346-8138.13408.CrossRefPubMedGoogle Scholar