Most of the patients with atopic dermatitis (AD) get better before about 10 years old. Although some patients get better and flare up once again after adolescence, some never get better and symptoms remain from childhood through to adulthood, and some have an onset after adolescence. and dirty neck are common among any type of AD of adolescent and adult, and other typical manifestations are also found.
Scratching the itchy spot for a long time and inappropriate treatment induce intractable chronic eczema. In the adolescent and adult patients of AD, the life and job environment directly affect the condition of their eruption. In addition, decreased perspiration in AD is one of the causes of skin dryness and decreased skin barrier function, so it is susceptible to complications like skin infectious disease.
Atopic dermatitis Adult phase Clinical manifestation Face erythema Dirty neck
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Hanifin JM, Rajka G. Diagnostic features of atopic dermatitis. Acta Derm Venereol. 1980;92:44–7.Google Scholar
The Japanese Dermatological Association. Definition and diagnostic criteria for atopic dermatitis. Jpn J Dermatol. 1994;104:1210. (in Japanese)Google Scholar
Saeki H, Nakahara T, Tanaka A, et al. Clinical practice guidelines for the management of atopic dermatitis 2016. J Dermatol. 2016;43:1117–45.CrossRefPubMedGoogle Scholar
Lewis WH, Marion BS, et al. Evolution of atopic dermatitis. Arch Derm Syphilol. 1935;32:451–63.CrossRefGoogle Scholar
Werner Y, Lindberg M. Transepidermal water loss in dry and clinically normal skin in patients with atopic dermatitis. Acta Derm Venereol. 1985;65(2):102–5.PubMedGoogle Scholar
Takahashi A, Tani S, Murota H, et al. Histamine modulates sweating and affects clinical manifestations of atopic dermatitis. Kerger Curr Probl Dermatol. 2016;51:50–6.CrossRefGoogle Scholar
Hajar T, Leshem YA, Hanifin JM, et al. A systematic review of topical corticosteroid withdrawal (“steroid addiction”) in patients with atopic dermatitis and other dermatoses. J Am Acad Dermatol. 2015;72(3):541–9.CrossRefPubMedGoogle Scholar
Oh SH, Bae BG, Park CO, et al. Association of stress with symptoms of atopic dermatitis. Acta Derm Venereol. 2010;90:582–8.CrossRefPubMedGoogle Scholar
Nilsson EJ, Knutsson A. Atopic dermatitis, nickel sensitivity and xerosis as risk factors for hand eczema in women. Contact Dermatitis. 1995;33:401–6.CrossRefPubMedGoogle Scholar
Arase N, Murakami Y, Takahashi A, et al. Analysis of work productivity and activity impairment (WPAI), quality of life (QOL) and healthcare costs for Japanese patients with hand eczema. J Environ Dermatol Cutan Allergol. 2013;7(2):87–92.Google Scholar
Hashimoto T, Satoh T, Yokozeki H. Protective role of STAT6 in basophil-dependent prurigo-like allergic skin inflammation. J Immunol. 2015;194(10):4631–40.CrossRefPubMedGoogle Scholar
Mukai H, Nishioka K, Kamimura K, et al. Poikiloderma-like lesions on the neck in atopic dermatitis: a histopathological study. J Dermatol. 1990;17(2):85–91.CrossRefPubMedGoogle Scholar
Schram ME, Leeflang MM, DEN Ottolander JP, et al. Validation and refinement of the Millennium Criteria for atopic dermatitis. J Dermatol. 2011;38(9):850–8.PubMedGoogle Scholar
Smith FJD, Irvine AD, Terron-Kwiatkowski A, et al. Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris. Nat Genet. 2006;38:337–42.CrossRefPubMedGoogle Scholar
Nemoto-Hasebe I, Akiyama M, Nomura T, Sandilands A, et al. FLG mutation p.Lys4021X in the C-terminal imperfect filaggrin repeat in Japanese patients with atopic eczema. Br J Dermatol. 2009;161(6):1387–90.CrossRefPubMedGoogle Scholar
Novak N, Baurecht H, Schafer T, et al. Loss-of-function mutations in the filaggrin gene and allergic contact sensitization to nickel. J Invest Dermatol. 2008;128:1430–5.CrossRefPubMedGoogle Scholar
Sergeant A, Campbell LE, Hull PR, et al. Heterozygous null alleles in filaggrin contribute to clinical dry skin in young adults and the elderly. J Invest Dermatol. 2009;129:1042–5.CrossRefPubMedGoogle Scholar
Brown SJ, Relton CL, Liao H, et al. Filaggrin null mutations and childhood atopic eczema: a population-based case–control study. J Allergy Clin Immunol. 2008;121:940–6.CrossRefPubMedGoogle Scholar
Brown SJ, Relton CL, Liao H, et al. Filaggrin haploinsufficiency is highly penetrant and is associated with increased severity of eczema: further delineation of the skin phenotype in a prospective epidemiological study of 792 school children. Br J Dermatol. 2009;161(4):884–9.CrossRefPubMedPubMedCentralGoogle Scholar