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Evolution of Animal Models of Atopic Dermatitis

  • Ichiro KatayamaEmail author
  • Kohsuke Yamaga
  • Hiroyuki Murota
Chapter

Abstract

Historically, several atopic dermatitis (AD) models have been introduced and applied for the understanding of human AD and evaluation of the clinical effect of new drugs.

After the establishment of transgenic technology, several transgenic or knockout mouse lines expressing atopic dermatitis-like phenotypes have been reported with promising results. However, it remains unclear as to whether Th2-type cytokines, IL-4, IL-5, or IL-13, play an essential role in the induction of the IgE-mediated reaction or if impaired skin barrier functions with abnormal itch perception play a more fundamental role in human atopic dermatitis.

Another point of discussion is whether IgE antibody itself induces spongiotic eczematous reactions occasionally observed in acute phases of human atopic dermatitis.

Keywords

Atopic dermatitis Animal model Monoclonal IgE antibody Transgenic/knockout mouse 

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Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Ichiro Katayama
    • 1
    Email author
  • Kohsuke Yamaga
    • 1
  • Hiroyuki Murota
    • 1
  1. 1.Department of Dermatology, Course of Integrated Medicine, Graduate School of MedicineOsaka UniversityOsakaJapan

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