History and Definition

  • Kiyoshi NishiokaEmail author


History of atopic dermatitis is reviewed. Atopic dermatitis was recognized as a chronic relapsing pruritic skin disease and called differently historically. Neurodermite disseminatus and prurigo diathetique are the distinct concepts leading to that of atopic dermatitis. Sulzburger established the concept of atopic eczema/dermatitis by introducing the concept of atopic hypersensitiveness to this skin disease. His idea was now widely accepted. In 1980 a new phenotype of atopic dermatitis appeared to us and was named adult-type atopic dermatitis. The mechanism and pathogenesis have been investigated extensively to define the real figure of this intractable skin disease.


Lichen simplex chronicus disseminatus Neurodermite disseminatus Prurigo diathetique Atopic dermatitis 


  1. 1.
    Mier PD. Earliest description of the atopic dermatitis. Br J Dermatol. 1975;92:359.CrossRefGoogle Scholar
  2. 2.
    Masuda T. Atopic dermatitis. In: Kitamura K, et al., editors. Japanese compendia of dermatology, Eczema and related diseases, vol. 3. Tokyo: Kanehara Pbl Co; 1967. p. 301–401.Google Scholar
  3. 3.
    Vidal E. Du lichen (lichen, prurigo, strophulus). Ann Dermatol Syph. 1886;7:133–54.Google Scholar
  4. 4.
    Brocq L, Jacquet L. Notes pour server a l’histoire des nevrodermites. Ann Dermatol Syphil. 1891;3:97–122, 193–208.Google Scholar
  5. 5.
    Willan R. Prurigo. On cutaneous diseases, vol. 1. London: Johnson J; 1808. p. 67–104.Google Scholar
  6. 6.
    Besnier ME. Premiere note et observations preliminaries pour server d’introduction a l’etude des prurigos diathesiques. Ann Dermatol Syph. 1892;3:634–47.Google Scholar
  7. 7.
    Coca AF, Cooke RA. On the classification of the phenomena of hypersensitiveness. J Immunol. 1922;3:163–82.Google Scholar
  8. 8.
    Bear RL. The development of the concept of atopic dermatitis. In: Bear RL, editor. Atopic dermatitis. New York: New York University Press; 1955. p. 1–9.Google Scholar
  9. 9.
    Hill LW, Sulzburger MB. Evolution of atopic dermatitis. Arch Derm Syphilol. 1935;32:451–63.Google Scholar
  10. 10.
    Sulzburger MB. Atopic dermatitis: its clinical and histologic picture. In: Bear RL, editor. Atopic dermatitis. New York: New York University Press; 1955. p. 11–42.Google Scholar
  11. 11.
    Rostenberg A Jr. Atopic dermatitis: a discussion of certain theories concerning its pathogenesis. In: Bear RL, editor. Atopic dermatitis. New York: New York University Press; 1955. p. 57–80.Google Scholar
  12. 12.
    Nishioka K, Mukai H, Kamimura K, Horiuchi Y, Itoh A, Noguchi T, Nishiyama S. Clinical course of severe cases with adult type atopic dermatitis. Jpn J Dermatol. 1988;98:873–7.Google Scholar
  13. 13.
    Nishioka K. Adult type atopic dermatitis. Clin Dermatol. 1991;33:413–8.Google Scholar
  14. 14.
    Mukai H, Nishioka K, Kamimura K, Katayama I, Nishiyama S. Poikiloderma-like lesions on the neck in atopic dermatitis: a histopathological study. J Dermatol. 1990;17:85–91.CrossRefPubMedGoogle Scholar
  15. 15.
    Nishioka K. Atopic eczema of adult type in Japan. Austral J Dermatol. 1996;37:S7–9.CrossRefGoogle Scholar
  16. 16.
    Nishioka K. Potent infection as the exacerbating factors of severe cases with atopic dermatitis of adult type. Allergy Immun. 2001;8:65–9.Google Scholar
  17. 17.
    Katayama I, Taniguchi H, Matsunaga T, Yokozeki H, Nishioka K. Evaluation of non-steroidal ointment therapy for adult type atopic dermatitis: inquiry analysis on clinical effect. J Dermatol Sci. 1997;14:37–44.CrossRefPubMedGoogle Scholar
  18. 18.
    Soumelis V, Reche PA, Kanzler H, Yuan W, Edward G, Homey B, et al. Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP. Nat Immunol. 2002;37:673–80.CrossRefGoogle Scholar
  19. 19.
    Novak N, Bieber T, Leung DYM. Immune mechanisms leading to atopic dermatitis. J Allergy Clin Immunol. 2003;112:S128–39.CrossRefPubMedGoogle Scholar
  20. 20.
    Smith FJD, Irvine AD, Terron-Kwiatkowski A, Sandilands A, Campbell LE, Zhao Y, et al. Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris. Nat Genet. 2006;36:337–42.CrossRefGoogle Scholar
  21. 21.
    Cork MJ, Robinson DA, Vasilopoulos Y, Ferguson A, Moustafa M, MacGowwan A, Duff GW, et al. New perspectives on epidermal barrier dysfunction in atopic dermatitis: gene-environment interactions. J Allergy Clin Immunol. 2006;118:3–21.CrossRefPubMedGoogle Scholar
  22. 22.
    Irvine AD, McLean WHI, Leung DYM. Filaggrin mutations associated with skin and allergic diseases. N Engl J Med. 2011;365:1315–27.CrossRefPubMedGoogle Scholar
  23. 23.
    Bieber T. Atopic dermatitis. N Engl J Med. 2008;358:1438–94.CrossRefGoogle Scholar
  24. 24.
    Kubo A, Nagao K, Amagai M. Epidermal barrier dysfunction and cutaneous sensitization in atopic dermatitis. J Clin Invest. 2012;122:440–7.CrossRefPubMedPubMedCentralGoogle Scholar
  25. 25.
    Kabashima K. New concept of the pathogenesis of atopic dermatitis: interplay among the barrier, allergy and pruritus as a trinity. J Dermatol Sci. 2013;70:3–11.CrossRefPubMedGoogle Scholar

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© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  1. 1.Hyogo Medical CollegeNishinomiya CityJapan

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