Allergy and Pollen

  • Jae-Won Oh


The understanding of allergy is growing exponentially with the ongoing expansion in our knowledge of the immune system. The immune system is the capacity to distinguish harmful non-self molecules from self-molecules, a characteristic that exists in a delicate balance between tolerance to self and response or rejection of non-self. This system is focused on host defense and is composed of specific cellular and protein components that develop and function in a highly complex manner, in order to neutralize or destroy dangerous non-self while preserving self.


  1. 1.
    Chinen J, Fleisher TA, Shearer WT. The immune system: an overview. In: Adkinson Jr NF, Bochner BS, Busse WW, Holgate ST, Lemanske RF, Simons EF, editors. Middleton’s allergy. Principles and practice. 7th ed. Mosby: Elsevier; 2009. p. 3–18.CrossRefGoogle Scholar
  2. 2.
    Smith EG. Sampling and identifying allergenic pollens and molds: an illustrated identification manual for air samplers. San Antonio: Belwtone; 1990.Google Scholar
  3. 3.
    Parkin J, Cohen B. An overview of the immune system. Lancet. 2001;357:1777–89.CrossRefPubMedGoogle Scholar
  4. 4.
    Delves PJ, Roitt IM. The immune system (in two parts). N Engl J Med. 2000;343:37–49.CrossRefPubMedGoogle Scholar
  5. 5.
    Romagnani S. The increasing prevalence of allergy and the hygiene hypothesis: missing immune deviation, reduced immune suppression, or both? Immunology. 2004;112:252–63.CrossRefGoogle Scholar
  6. 6.
    Heinrich J, Wichmann HE. Traffic related pollutants in Europe and their effect on allergic disease. Curr Opin Allergy Clin Immunol. 2004;4:341–8.CrossRefPubMedGoogle Scholar
  7. 7.
    Platts-Mills TA, Erwin E, Heymann P, et al. Is the hygiene hypothesis still a viable explanation for the increased prevalence of asthma? Allergy. 2005;60(S79):25–31.CrossRefPubMedGoogle Scholar
  8. 8.
    Riedler J, Braun-Fhranlander C, Eder W, et al. Exposure to farming early in life and development of asthma and allergy: a cross sectional survey. Lancet. 2001;116:675–82.Google Scholar
  9. 9.
    Ober C. Asthma genetics the long and winding road to gene discovery. Genes Immun. 2006;7:95–100.CrossRefPubMedGoogle Scholar
  10. 10.
    Kurz T, Hoffjan S, Hayes MG, et al. Final mapping and positional candidatestudies on chromosome 5p13 identify multiple asthma susceptibility loci. J Allergy Clin Immunol. 2006;118:396–402.CrossRefPubMedGoogle Scholar
  11. 11.
    Basehore MJ, Howard TD, Lange LA, et al. A comprehensive evaluation of IL-4 varients in ethnically diverse populations: association of total serum IgE levels and asthma in white subjects. J Allergy Clin Immunol. 2004;114:80–7.CrossRefPubMedGoogle Scholar
  12. 12.
    King TP, Hoffman D, Lowenstein H, et al. Allergen nomenclature. Allergy. 1995;50:765–74.CrossRefPubMedGoogle Scholar
  13. 13.
    Faegri K, van der Pijl F. The principles of pollination ecology. Oxford: Pergamon; 1979.Google Scholar
  14. 14.
    Schäppi GF, Taylor PE, Staff IA, Rolland JM, Suphioglu C. Immunologic significance of respirable atmospheric starch granules containing major birch allergen Bet v 1. Allergy. 1999;54:478–83.CrossRefPubMedGoogle Scholar
  15. 15.
    Weber RW. Pollen identification. Ann Allergy Asthma Immunol. 1998;80:141–7.CrossRefPubMedGoogle Scholar
  16. 16.
    Schäppi GF, Taylor PE, Pain MCF, et al. Concentrations of major grass group 5 allergens in pollen grains and atmospheric particles: implications for hay fever and allergic asthma sufferers sensitized to grass pollen allergens. Clin Exp Allergy. 1999;29:633–41.CrossRefPubMedGoogle Scholar
  17. 17.
    Grote M, Vrtala S, Niederberger V, Valenta R, Reichelt R. Expulsion of allergen-containing materials from hydrated ryegrass. J Allergy Clin Immunol. 2000;105:1140–5.CrossRefPubMedGoogle Scholar
  18. 18.
    Grote M, Swoboda I, Valenta R, Reichelt R. Group 13 allergens as environmental and immunological markers for grass pollen allergy: studies by immunogold field emission scanning and transmission electron microscopy. Int Arch Allergy Immunol. 2005;136:303–10.CrossRefPubMedGoogle Scholar
  19. 19.
    Kendrick B. The fifth kingdom. Waterloo: Mycologue Publications; 1985.Google Scholar
  20. 20.
    Gold BL, Matthews KP, Burge HA. Occupational asthma caused by sewer flies. Am Rev Respir Dis. 1985;131:949–52.PubMedGoogle Scholar
  21. 21.
    Elfman L, Brannstrom J, Smedje G. Detection of horse allergen around a stable. Int Arch Allergy Immunol. 2008;145:269–76.CrossRefPubMedGoogle Scholar
  22. 22.
    Stewart GA. The molecular biology of allergens. In: Busse WW, Holgate ST, editors. Asthma and rhinitis. Boston: Blackwell Scientific; 2000. p. 1107–42.CrossRefGoogle Scholar
  23. 23.
    Solomon WR, Burge HA, Muilenberg ML. Allergen carriage by atmospheric aerosol. I. Ragweed pollen determinants in smaller micronic fractions. J Allergy Clin Immunol. 1972;50:289–93.CrossRefGoogle Scholar
  24. 24.
    Busse WW, Reed CE, Hoehne JH. Where is the allergic reaction in ragweed asthma? J Allergy Clin Immunol. 1972;50:289–93.CrossRefPubMedGoogle Scholar
  25. 25.
    Demoly P, Bousquet J, Romano A. In vivo methods for the study of allergy. In: Adkinson Jr NF, Bochner BS, Busse WW, Holgate ST, Lemanske RF, Simons EF, editors. Middleton’s allergy. Principles and practice. 7th ed. Mosby: Elsevier; 2009. p. 1268–80.Google Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Jae-Won Oh
    • 1
  1. 1.Division of Allergy and Clinical Immunology, Department of PediatricsHanyang University College of MedicineSeoulRepublic of Korea

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