Abstract
Milk proteins are nutritionally significant for the children under 5 years of age. Proteins are the necessary building blocks of body tissues and provide amino acids essential for the growth and development of body of preschool children and their higher cognitive functions. Casein is important milk protein which is phosphoprotein in nature. It is precipitated in stomach and is the cause of delayed absorption of casein protein in children and infants. Conversely, whey protein’s digestibility and absorption are comparatively rapid from mucosa of GIT. Human breast milk is an important source of taurine and cystine amino acids. It is advisory for infants that who have allergy to cow milk should be provided human breast milk. It has been proved that feeding of infants with cow milk early in life might provoke immunological response in a few infants which in turn become a breeding ground for pathogenesis of iron deficiency and zinc depletion in infant’s body. Otherwise, exclusive breast-feeding of infants during initial 6 months and relative restriction from the start of cow milk are worthwhile practices to prevent cow milk protein allergy and associated clinical manifestations.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
American Academy of Pediatrics (1992) The use of whole cow’s milk in infancy. Pediatrics 89:1105–1109
Anderson GH, Morson-Pasut LA, Bryan H, Clegorn G, Tanaka P, Yeung D, Zimmerman B (1985) Age of introduction of cow’s milk to infants. J Pediatr Gastroenterol Nutr 4:692–698
Atkinson S, Lonnerdal B (1989) Protein and non protein nitrogen in human milk. CRC Press, Boca Raton, Florida, pp 139–140
Barth CA, Behnke U (1997) Nutritional significance of whey and whey components. Nahrung 41:2–12
Boirie Y, Dangin M, Gachon P, Vasson MP, Maubois JL (1997) Slow and fast dietary proteins differently modulate post prandial protein accretion. Proc Natl Acad Sci 94(26):14930–14935
Chesney RW, Helms RA, Christensen M, Budreau AM, Han X, Sturman JA (1998a) An updated view of the value of taurine in infant nutrition. Adv Pediatr 40:179–200
Chesney RW, Helms RA, Christensen M, Budreau AM, Han X, Sturman JA (1998b) The role of taurine in infant nutrition. Adv Exp Med Biol 442:463–476
Dallman PR, Siimes MA, Stekel A (1980) Iron deficiency in infancy and childhood. Am J Clin Nutr 33:86–118
De Angelis RC, Ctenas ML. Biodisponibilidade de ferro na alimentação infantil. Temas de Pediatria, Nestlé, 52; 1993
Fomon SJ, Sanders KD, Ziegler EE (1990) Formulas for older infants. J Pediatr 116:690–696
Fruhbeck G (1998) Slow and fast dietary protein. Nature 391(6670):843–945
Fuchs GJ, Gastanaduy AS, Suskind RM (1992) Comparative metabolic study of older infants fed infant formula, transition formula, or whole cow’s milk. Nutr Res 12:1467–1478
Gunnarsson BS, Thorsdottir I, Palsson G (2005) Iron status in 6-yold children: association with growth and earlier iron status. Eur J Clin Nutr 59:761–767
Hadler MC, Colugnati FA, Sigulem DM (2004) Risks of anemia in infants according to dietary iron density and weight gain rate. Prev Med 39:713–721
Hallberg L, Rossander-Hulthén L, Brune M, Gleerup A (1992a) Bioavailability in man of iron in human milk and cow’s milk in relation to their calcium contents. Pediatr Res 31:524
Hallberg L, Rossander-Hultén L, Brune M, Gleerup A (1992b) Calcium and iron absorption: mechanism of action and nutritional importance. Eur J Clin Nutr 46:317–327
Hambraeus L (1982) Nutritional aspects of milk proteins. In: Fox PF (ed) Developments in dairy chemistry–1: proteins. Applied Science Publishers, London, pp 289–313
Hambraeus L (1992) Nutritional aspects of milk proteins. In: Fox PF (ed) Advanced dairy chemistry–1: proteins. Elsevier Applied Science, London, pp 457–490
Hattevig G, Kjellman B, Sigurs N, Bjorksten B, Kjellman N (1989) Effect of maternal avoidance of eggs, cow’s milk and fish during lactation upon allergic manifestations in infants. Clin Exp Allergy 19(1):27–32
Hermoso M, Vucic V, Vollhardt C, Arsic A, Roman-Vinas B, Iglesia-Altaba I, Gurinovic M, Koletzko B (2011) The effect of iron on cognitive development and function in infants, children and adolescents: a systematic review. Ann Nutr Metab 59:154–165
Host A, Husby S, Osterballe O (1988) A prospective study of cow’s milk allergy in exclusively breast-fed infants. Acta Paediatr Scand 77:663–670
Howard D, Thompson DF (1992) Taurine: an essential amino acid to prevent cholestasis in neonates. Ann Pharmacother 26:1390–1392
Hurrel RF, Lynch SR, Trinidad TP, Dassenko SA, Cook JD (1989) Iron absorption in humans as influenced by bovine milk proteins. Am J Clin Nutr 49:546–552
Jakobsson I, Lindberg T, Benediktsson B, Hansson BG (1985) Dietary bovine beta-lactoglobulin is transferred to human milk. Acta Paediatr Scand 74(3):342–345
Jiang T, Jeter JM, Nelson SE, Ziegler EE (2000) Intestinal blood loss during cow milk feeding in older infants. Arch Pediatr Adolesc Med 154:673–678
Kazal OA Jr (2002) Prevention of iron deficiency in infants and toddlers. Am Fam Physician 66(7):1217–1225
Kunz C, Lonnerdal B (1990) Human milk protein: analysis of casein and casein subunits by anion exchange chromatography, gel electrophoresis and specific staining methods. Am J Clin Nutr 51(1):37–46
Leung AK, Chan KW (2001) Iron deficiency anemia. Adv Pediatr Infect Dis 48:385–408
Lija G, Dannaeus A, Foucard T, Graff-Lonnevig V, Johansson SG, Oman H (1989) Effects of maternal diet during late pregnancy and lactation on the development of atopic diseases in infants up to 18 months of age – in-vivo results. Clin Exp Allergy 19(4):473–479
Louis A, Kazal JR (2002) Prevention of iron deficiency in infants and toddlers. Am Fam Physician 66(7):1217–1225
Mahe S, Roos N, Benamouzig R, Davin L, Luengo C, Gabnon L, Gausserges N, Rautureaux JL, Tome D (1966) Gastrojejunal kinetics and the digestion of [15N]beta-lactoglobulin and casein in humans: the influence of the nature and quantity of the protein. Am J Clin Nutr 63:546–552
Male C, Persson LA, Freeman V, Guerra A, van’t Hof MA, Haschke F (2001) Prevalence of iron deficiency in 12-mo-old infants from 11 European areas and influence of dietary factors on iron status (Euro-Growth study). Acta Paediatr 90:492–498
Morr CV (1989) Whey proteins: manufacture. In: Fox PF (ed) Developments in dairy chemistry–4: proteins. Elsevier Science Publishers, London, pp 245–248
Mulvihill DM (1992) Production, functional properties and utilization of milk protein products. In: Fox PF (ed) Advanced dairy chemistry–1: proteins. Elsevier Science Publishers, London, pp 369–404
Oliveira MA, Osorio MM (2005) Cow’s milk consumption and iron deficiency anemia in children. J Pediatr 81(5):361–367
Oski FA (1993) Iron deficiency in infancy and childhood. N Engl J Med 329:190–193
Osorio MM, Lira PI, Ashworth A (2001) Prevalence of anemia in children 6–59 months old in the state of Pernambuco, Brazil. Pan Am J Public Health 10:101–107
Paganelli R, Cavangni G, Pallone F (1986) The role of antigenic absorption and circulating immune complexes in food allergy. Ann Allergy 57:330–336
Penrod JC, Anderson K, Acosta PB (1990) Impact of iron status of introducing cow’s milk in the second six months of life. J Pediatr Gastroenterol Nutr 10:462–467
Pipes PL (1997) Infant feeding and nutrition. In: Trahms CM, Pipes PL (eds) Nutrition in infancy and childhood. McGraw Hill, New York, pp 98–129
Pizarro F, Yip R, Dallman PR, Olivares M, Her-trampf E, Walter T (1991) Iron status with different infant feeding regimens: relevance to screening and prevention of iron deficiency. J Pediatr 118:687–692
Rassin DK, Sturman JA, Guall GE (1978) Taurine and other free amino acids in milk of man and other mammals. Early Hum Dev 2:1–13
Rolland-Cachera MF, Deheeger M, Bellisle F (1999) Increasing prevalence of obesity among 18-year-old males in Sweden: evidence for early determinants. Acta Paediatr 88:365–367
Sadowitz PD, Oski FA (1983) Iron status and infant feeding practices in an urban ambulatory center. Pediatrics 72:33–36
Sazawal S, Dhingra U, Dhingra P (2010) Micronutrient fortified milk improves iron status, anemia and growth among children 1–4 years: a double masked, randomized, controlled trial. PLoS One 5:e12167
Sigurs N, Hattevig G, Kjellman B (1992) Maternal avoidance of eggs, cow’s milk and fish during lactation: effect on allergic manifestations, skin-prick tests, and specific IgE antibodies in children at age 4 years. Pediatrics 89:735–739
Sindayikengera S, Xia WS (2006) Nutritional evaluation of caseins and whey proteins and their hydrolysates from Protamex. J Zhejiang Univ Sci B 7(2):90–98
Spencer AU, Yu S, Tracy TF (2005) Parenteral nutrition-associated cholestasis in neonates: multivariate analysis of the potential protective effect of taurine. J Parenter Enter Nutr 29:337–343
Sturman JA, Chesney RW (1995) Taurine in pediatric nutrition. Pediatr Clin N Am 42:879–897
Szajewska H, Ruszczynski M, Chmielewska A (2010) Effects of iron supplementation in nonanemic pregnant women, infants, and young children on the mental performance and psychomotor development of children: a systematic review of randomized controlled trials. Am J Clin Nutr 91:1684–1690
Tunnessen WW Jr, Oski FA (1987) Consequences of starting whole cow milk at 6 months of age. J Pediatr 111(6 pt 1):813–816
Walstra P, Jenness R (1984) Dairy chemistry and physics. Willey, New York, pp 114–122
Watkins JB, Jarvenpaa AL, Szczepanik-Van Leeuwen P (1983) Feeding the low-birth weight infant: effects of taurine, cholesterol, and human milk on bile acid kinetics. Gastroenterology 85:793–800
Wilson JF, Lahey ME, Heiner DC (1974) Studies on iron metabolism. V. Further observations on cow’s milk-induced gastrointestinal bleeding in infants with iron-deficiency anemia. J Pediatr 84:335–344
Woodruff CW, Wright SW, Wrigth RP (1972) The role of fresh cow’s milk in iron deficiency: II. Comparison of fresh cow’s milk with a prepared formula. Am J Dis Child 124:26
World Health Organization (1998) Complementary feeding of young children in developing countries. A review of current scientific knowledge. WHO, Geneva
Ziegler EE (1990) Milk and formulas for older infants. J Pediatr 117:S76–S79
Ziegler EE (2007) Adverse effects of cow’s milk in infants. Nestle Nutr Workshop Ser Pediatr Program 60:185–196
Ziegler EE (2011) Consumption of cow’s milk as a cause of iron deficiency in infants and toddlers. Nutr Rev 69(Suppl 1):S37–S42
Ziegler EE, Fomson SJ, Nelson SE, Rebouche CJ, Edward BB, Rogers RR, Lehman LJ (1990) Cow milk feeding in infancy: further observations on blood loss from the gastrointestinal tract. J Pediatr 116(1):11–18
Ziegler EE, Jiang T, Romero E, Vinco A, Frantz JA, Nelson SE (1999) Cow’s milk and intestinal blood loss in late infancy. J Pediatr 135:720–726
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2017 Springer Nature Singapore Pte Ltd.
About this chapter
Cite this chapter
Gupta, A. (2017). Infants’ Consumption of Cow Milk and Anemia. In: Nutritional Anemia in Preschool Children. Springer, Singapore. https://doi.org/10.1007/978-981-10-5178-4_13
Download citation
DOI: https://doi.org/10.1007/978-981-10-5178-4_13
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-10-5177-7
Online ISBN: 978-981-10-5178-4
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)