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Treatment planning of microbrachytherapy with 3D NSGA-II

  • Conference paper
  • First Online:
EMBEC & NBC 2017 (EMBEC 2017, NBC 2017)

Part of the book series: IFMBE Proceedings ((IFMBE,volume 65))

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Abstract

An innovative form of radiotherapy, microbrachytherapy, is under development for solid, inoperable, radioresistant tumors. A method of treatment planning is proposed using a multi-objective algorithm, NSGA-II.

A suitable treatment plan was found that treated the tumor (a sphere of 10 mm radius) with 6 injections. Each injection had a volume of 5 µL, containing 90Y microspheres with an initial activity of 50 MBq.

The treatment plan respected both the constraint on the tumor (95% of the tumor to receive at least 95% of the target dose, 100 Gy) and the constraint on a nearby organ at risk (no more than 10% of the organ to receive over 10 Gy).

Optimization time was less than 7 minutes for a population of 800 treatment plans over 100 generations with a 2.5 GHz quad-core MacBook Pro.

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Author information

Authors and Affiliations

  1. Inserm, UMR1037 CRCT, Avenue Hubert Curien, F-31000, Toulouse, France

    Richard Brown, Manuel Bardiès & Xavier Franceries

  2. Université Toulouse III-Paul Sabatier, UMR1037 CRCT, F-31000, Toulouse, France

    Richard Brown, Manuel Bardiès & Xavier Franceries

Authors
  1. Richard Brown
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  2. Manuel Bardiès
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  3. Xavier Franceries
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Corresponding author

Correspondence to Richard Brown .

Editor information

Editors and Affiliations

  1. Tampere University of Technology, BioMediTech Institute and Faculty of Biomedical Science and Engineering, Tampere, Finland

    Hannu Eskola

  2. Tampere University of Technology, BioMediTech Institute and Faculty of Biomedical Science and Engineering, Tampere, Etelä-Suomi, Finland

    Outi Väisänen

  3. Tampere University of Technology, BioMediTech Institute and Faculty of Biomedical Science and Engineering, Tampere, Etelä-Suomi, Finland

    Jari Viik

  4. Tampere University of Technology, BioMediTech Institute and Faculty of Biomedical Science and Engineering, Tampere, Etelä-Suomi, Finland

    Jari Hyttinen

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© 2018 Springer Nature Singapore Pte Ltd.

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Brown, R., Bardiès, M., Franceries, X. (2018). Treatment planning of microbrachytherapy with 3D NSGA-II. In: Eskola, H., Väisänen, O., Viik, J., Hyttinen, J. (eds) EMBEC & NBC 2017. EMBEC NBC 2017 2017. IFMBE Proceedings, vol 65. Springer, Singapore. https://doi.org/10.1007/978-981-10-5122-7_113

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  • DOI: https://doi.org/10.1007/978-981-10-5122-7_113

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-10-5121-0

  • Online ISBN: 978-981-10-5122-7

  • eBook Packages: EngineeringEngineering (R0)

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