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Intra-cellular Calcium Release Dynamics Due to Nanosecond Electric Pulsing

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Ultrashort Electric Pulse Effects in Biology and Medicine

Part of the book series: Series in BioEngineering ((SERBIOENG))

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Abstract

Permeabilization of cell membranous structures by nanosecond electric field pulses triggers a transient rise of cytosolic calcium with multifarious downstream effects. Electroporation of intracellular membranes (such as those of the Endoplasmic Reticulum) are likely responsible for the calcium release. This is an important application of pulsed electric fields, since calcium is known as a ubiquitous second messenger molecule that regulates several responses in cell signaling, including enzyme activation, gene transcription, neurotransmitter release, secretion, muscle contraction etc. In this chapter, a model based analysis of the dynamical calcium release in response to an external electric pulse is discussed. The results obtained are shown to match experimental data fairly well.

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Authors and Affiliations

  1. Department of Electrical and Computer Engineering, Texas Tech University, Lubbock, TX, USA

    Ravi Joshi

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  1. Ravi Joshi
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Correspondence to Ravi Joshi .

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Joshi, R. (2021). Intra-cellular Calcium Release Dynamics Due to Nanosecond Electric Pulsing. In: Ultrashort Electric Pulse Effects in Biology and Medicine. Series in BioEngineering. Springer, Singapore. https://doi.org/10.1007/978-981-10-5113-5_6

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  • DOI: https://doi.org/10.1007/978-981-10-5113-5_6

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-10-5112-8

  • Online ISBN: 978-981-10-5113-5

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