Abstract
Generally, in studies of the bioelectric effects of nanosecond pulses, thermal effects are not considered. While this is certainly true for the delivery of single or a small number of pulses, developments in medical treatment based on tissue ablation have been based pulse trains applied at a high repetition rate. In fact, temperature increases may trigger thermally activated bioeffects. This suggests technological opportunities for electro-manipulation that takes advantage of synergisms between thermal and electrically driven processes. Even with modest temperature changes, large thermal gradients could be established, which in itself can lead to additive electric field creation. The focus in this chapter is on thermal aspects and the possible synergies with electrical stimulation for bio-effects.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
References
Berendsen JC, van der Spoel D, van Drunen R (1995) GROMACS - A Message-passing parallel molecular-dynamics implementation. Comput Phys Commun 95:43–56
Bresme F, Lervik A, Bedeaux D, Kjelstrup S (2008) Water polarization under thermal gradients. Phys Rev Lett 101: 020602/1–4.
Camp JT, Jing Y, Zhuang J, Beebe SJ, Song J, Joshi RP, Schoenbach KH (2012) Cell death induced by subnanosecond pulsed electric fields at elevated temperatures. IEEE Trans Plasma Sci 40:2334–2347
Chen W, Zhang J (2006) Using nanoparticles to enable simultaneous radiation and photodynamic therapies for cancer treatment. J Nanosci Nanotechnol 6:1159–1166
Croce RP, De Vita A, Pierro V, Pinto IM (2010) A thermal model for pulsed EM field exposure effects in cells at nonthermal levels. IEEE Trans Plasma Sci 38:149–155
Davio SR, Low PS (1982) Characterization of the calorimetric C-transition of the human erythrocyte membrane. Biochemistry 21:3575–3582
Du Q, Superfine R, Freysz E, Shen YR (1993) Vibrational spectroscopy of water at the vapor/water interface. Phys Rev Lett 70:2313–2316
Eastman E (1926) Thermodynamics of non-isothermal systems. J Am Chem Soc 48:1482–1493
Eastman E (1928) Theory of the Soret effect. J Am Chem Soc 50:283–291
Garner AL, Deminsky M, Neculaes VB, Chashihin V, Knizhnik A, Potapkin B (2013) Cell membrane thermal gradients induced by electromagnetic fields. J Appl Phys 133:214701/1-11
Garner AL, Neculaes VB, Deminsky M, Dylov DV, Joo C, Loghin ER, Yazdanfar S, Conway KR (2016) Plasma membrane temperature gradients and multiple cell permeabilization induced by low peak power density femtosecond lasers. Biochem Biophys Rep 5:168–174
Govorov AO, Zhang W, Skeini T, Richardson H, Lee J, Kotov NA (2006) Gold nanoparticle ensembles as heaters and actuators: melting and collective plasmon resonances. Nanoscale Res Lett 1:84–90
Hornef J, Edelblute CM, Schoenbach KH, Heller R, Guo S, Jiang C (2020) Thermal analysis of infrared irradiation-assisted nanosecond-pulsed tumor ablation. Sci Rep 10:5122
Hu Q, Zhang Z, Qiu H, Kong M, Joshi RP (2013) Physics of nanoporation and water entry driven by a high-intensity, ultrashort electrical pulse in the presence of cellular hydrophobic interactions. Phys Rev E 87:032704/1-9
Ivanov IT (1999) Investigation of surface and shape changes accompanying the membrane alteration responsible for the heat-induced lysis of human erythrocytes. Colloids Surf B 13:311–323
Jiang HR, Wada H, Yoshinaga N, Sano M (2009) Manipulation of colloids by a nonequilibrium depletion force in a temperature gradient. Phys Rev Lett 102: 208301/1-5
Joshi RP, Hu Q, Schoenbach KH, Beebe SJ (2005) Simulations of transient membrane behavior in cells subjected to a high-intensity ultrashort electric pulse. Phys Rev E 71:031914/1-9
Kotnik T, Miklavčič D (2000) Theoretical evaluation of the distributed power dissipation in biological cells exposed to electric fields. Bioelectromagnetics 21:385–394
Leonenko ZV, Finot E, Ma H, Dahms TES, Cramb DT (2004) Investigation of temperature-induced phase transitions in DOPC and DPPC phospholipid bilayers using temperature-controlled scanning force microscopy. Biophys J 86:3783–3793
Luzar A, Svetina S, Zeks B (1985) Consideration of the spontaneous polarization of water at the solid/liquid interface. J Chem Phys 82:5146–5154
Muscatello J, Romer J, Sala J, Bresme F (2011) Water under temperature gradients: polarization effects and microscopic mechanisms of heat transfer. Phys Chem Chem Phys 13:19970–19978
Narita M, Shimizu S, Ito T, Chittenden T, Lutz RJ, Matsuda H, Tsujimoto Y (1998) Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria. Proc Natl Acad Sci USA 95:14681–14686
Neumann E, Sowers AE, Jordan CA (1989) Electroporation and electrofusion in cell biology. Plenum Press, New York
Nijhuis EHA, Poot AA, Feijen J, Vermes I (2006) Induction of apoptosis by heat and c-radiation in a human lymphoid cell line; role of mitochondrial changes and caspase activation. Int J Hyperth 22:687–698
Pakhomov AG, Doyle J, Stuck BE, Murphy MR (2003) Effects of high power microwave pulses on synaptic transmission and long term potentiation in hippocampus. Bioelectromagnetics 24:174–181
Pierro V, De Vita A, Croce RP, Pinto IM (2014) Membrane heating in living tissues exposed to nonthermal pulsed EM fields. IEEE Trans Plasma Sci 42:2236–2244
Richardson HH, Hickmaan ZN, Govorov AO, Thomas AC, Zhang W, Kordesch M (2006) Thermooptical properties of gold nanoparticles embedded in ice: characterization of heat generation and melting. Nano Lett 6:783–788
Song J, Garner AL, Joshi RP (2017) Effects of thermal gradients created by electromagnetic fields on cell membrane electroporation probed by molecular dynamics simulations. Phys Rev Appl 7:024003
Song J, Joshi RP, Schoenbach KH (2011) Synergistic effects of local temperature enhancements on cellular responses in the context of high-intensity, ultrashort electric pulses. Med Biol Eng Comput 49:713–718
Swillens S, Dupont G, Combettes L, Champeil P (1999) From calcium blips to calcium puffs: theoretical analysis of the requirements for interchannel communication. Proc Natl Acad Sci 96:13750–13755
Vernier PT, Sun Y, Marcu L, Craft CM, Gundersen MA (2004) Nanoelectropulse-induced phosphatidylserine translocation. Biophys J 86:4040–4048
Weaver JC, Chizmadzhev Y (1996) Theory of electroporation: a review. Bioelectrochem Bioenerg 41:135–160
Wiegand S (2004) Thermal diffusion in liquid mixtures and polymer solutions. J Phys Cond Matt 16:R357–R379
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
Copyright information
© 2021 Springer Nature Singapore Pte Ltd.
About this chapter
Cite this chapter
Joshi, R. (2021). Synergy Between Electric Pulse and Thermal Effects. In: Ultrashort Electric Pulse Effects in Biology and Medicine. Series in BioEngineering. Springer, Singapore. https://doi.org/10.1007/978-981-10-5113-5_12
Download citation
DOI: https://doi.org/10.1007/978-981-10-5113-5_12
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-10-5112-8
Online ISBN: 978-981-10-5113-5
eBook Packages: EngineeringEngineering (R0)