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Model Rate Equation Evaluation of an Extrinsic Apoptotic Pathway

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Ultrashort Electric Pulse Effects in Biology and Medicine

Part of the book series: Series in BioEngineering ((SERBIOENG))

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Abstract

Apoptosis is one of the most complex signaling pathways, and can be triggered by a number of factors, radiation, chemotherapeutic drugs, electric field application, etc. The apoptotic pathways can generally be divided into signaling via the death receptors (extrinsic pathway) or the mitochondria effects (intrinsic pathway), and each pathway implies caspases as effector molecules. The role and extent of electric field modifications to the apoptotic pathways remains unclear. Here in this chapter, we attempt to qualitatively probe some of the issues pertaining to apoptotic cell death based on simple model simulations. The objectives of the present discussions are: (i) to determine if a pulse-number threshold might suitably apply to cell killing by nano-second, high-intensity pulses, and (ii) to assess whether the intrinsic or the extrinsic pathway is more dominant following electric pulsing.

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Authors and Affiliations

  1. Department of Electrical and Computer Engineering, Texas Tech University, Lubbock, TX, USA

    Ravi Joshi

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  1. Ravi Joshi
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Correspondence to Ravi Joshi .

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Joshi, R. (2021). Model Rate Equation Evaluation of an Extrinsic Apoptotic Pathway. In: Ultrashort Electric Pulse Effects in Biology and Medicine. Series in BioEngineering. Springer, Singapore. https://doi.org/10.1007/978-981-10-5113-5_10

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  • DOI: https://doi.org/10.1007/978-981-10-5113-5_10

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-10-5112-8

  • Online ISBN: 978-981-10-5113-5

  • eBook Packages: EngineeringEngineering (R0)

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