Abstract
Image magnification endoscopy is defined by the capacity to perform optical zoom by adjusting the position of the movable lens at the tip of the endoscope. Optical zoom endoscopes can magnify images up to 150 times. Image magnification endoscopy can provide detailed surface structure and vascular observation of gastrointestinal lesions. The evaluations via image magnification endoscopy usually are performed in combination with dye-based or mucosal enhancement techniques. Image magnification endoscopy has been reported to be helpful in evaluation and analysis of Barrett’s esophagus, squamous cell neoplasms of esophagus, gastric neoplasms, Helicobacter pylori gastritis, atrophic gastritis, intestinal metaplasia, colorectal neoplasms, and inflammatory bowel disease. Image magnification endoscopy is helpful for improvement in detection and classification of gastrointestinal mucosal lesions and minimizing tissue biopsies via better targeting. Further refinement of current endoscopic classifications for abnormality of gastrointestinal mucosal lesion and studies about high-magnification endoscopy compared with tissue biopsy will be used for delicate diagnosis and therapeutic decision making for gastrointestinal disease.
Confocal laser endomicroscopy (CLE) is a newly developed technique that allows real-time in vivo imaging of gastrointestinal mucosal layer. CLE can obtain greatly high magnification, enabling ×1000 magnification for real-time in vivo histological assessment by “confocal” method. CLE allows gastrointestinal endoscopists to notice changes in vessels, connective tissue, and cellular or subcellular structures, which were previously done through histological biopsy. Even though there are some limitations which make it difficult to expand its clinical use, such as extremely narrow field of view and high cost, there are many advantages of CLE applied in diverse spectrum of gastrointestinal diseases.
The section of Zoom endoscopy (32.1) was written by Chul-Hyun Lim and Confocal endoscopy section (32.2) was written by Jun Chul Park.
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References
Bruno MJ. Magnification endoscopy, high resolution endoscopy, and chromoscopy; towards a better optical diagnosis. Gut. 2003;52(Suppl 4):iv7–11.
Committee AT. High-definition and high-magnification endoscopes. Gastrointest Endosc. 2014;80(6):919–27.
Yao K, Anagnostopoulos GK, Ragunath K. Magnifying endoscopy for diagnosing and delineating early gastric cancer. Endoscopy. 2009;41(5):462–7.
Edebo A, Tam W, Bruno M, Van Berkel AM, Jonson C, Schoeman M, et al. Magnification endoscopy for diagnosis of nonerosive reflux disease: a proposal of diagnostic criteria and critical analysis of observer variability. Endoscopy. 2007;39(3):195–201.
Sharma P, Wani S, Bansal A, Hall S, Puli S, Mathur S, et al. A feasibility trial of narrow band imaging endoscopy in patients with gastroesophageal reflux disease. Gastroenterology. 2007;133(2):454–64. quiz 674
Kiesslich R, Fritsch J, Holtmann M, Koehler HH, Stolte M, Kanzler S, et al. Methylene blue-aided chromoendoscopy for the detection of intraepithelial neoplasia and colon cancer in ulcerative colitis. Gastroenterology. 2003;124(4):880–8.
Sharma P, Weston AP, Topalovski M, Cherian R, Bhattacharyya A, Sampliner RE. Magnification chromoendoscopy for the detection of intestinal metaplasia and dysplasia in Barrett's oesophagus. Gut. 2003;52(1):24–7.
Polglase AL, McLaren WJ, Skinner SA, Kiesslich R, Neurath MF, Delaney PM. A fluorescence confocal endomicroscope for in vivo microscopy of the upper- and the lower-GI tract. Gastrointest Endosc. 2005;62:686–95.
Kiesslich R, Gossner L, Goetz M, Dahlmann A, Vieth M, Stolte M, et al. In vivo histology of Barrett’s esophagus and associated neoplasia by confocal laser endomicroscopy. Clin Gastroenterol Hepatol. 2006;4:979–87.
Zhang HP, Yang S, Chen WH, Hu TT, Lin J. The diagnostic value of confocal laser endomicroscopy for gastric cancer and precancerous lesions among Asian population: a system review and meta-analysis. Scand J Gastroenterol. 2017;52:382–8.
Shahid MW, Buchner AM, Coron E, Woodward TA, Raimondo M, Dekker E, et al. Diagnostic accuracy of probe-based confocal laser endomicroscopy in detecting residual colorectal neoplasia after EMR: a prospective study. Gastrointest Endosc. 2012;75:525–33.
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Lim, CH., Park, J.C. (2018). Image Magnification Endoscopy. In: Chun, H., Yang, SK., Choi, MG. (eds) Clinical Gastrointestinal Endoscopy. Springer, Singapore. https://doi.org/10.1007/978-981-10-4995-8_32
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DOI: https://doi.org/10.1007/978-981-10-4995-8_32
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