Abstract
The present chapter highlights the structural properties of amino acids and organization of proteins into primary, secondary, tertiary, and quaternary structures. The concept of dihedral angles and Ramachandran plot is given to provide an understanding of the thermodynamically feasible protein conformations. The biophysical concepts of structural hierarchy are explained with the help of suitable examples. A deep understanding of various folds and motifs is provided to clear the theoretical aspects of protein structure and its functional implications including the recently discovered novel fold. Besides thermodynamic parameters of structural organization, various covalent and noncovalent interactions that play an important role in protein structure are explained. The important globin-containing proteins, namely, hemoglobin, myoglobin, cytochromes, and lysozyme, have been discussed with respect to their structural features responsible for their functioning. Further, the structural aspects of integral and peripheral membrane proteins are elaborated.
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Acknowledgment
JHCS is supported by FAPESP (grant 2014/12445-0) and CNPq. GM acknowledges the contribution of her students Ms. Muskan Chaddha and Romasha Gupta toward figures.
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Smetana, J.H.C., Misra, G. (2017). Principles of Protein Structure and Function. In: Misra, G. (eds) Introduction to Biomolecular Structure and Biophysics. Springer, Singapore. https://doi.org/10.1007/978-981-10-4968-2_1
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DOI: https://doi.org/10.1007/978-981-10-4968-2_1
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