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Fungal Differentiation: A Model Phenomenon to Screen Antifungal Drugs

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Developments in Fungal Biology and Applied Mycology

Abstract

Pathogenic fungi change the morphology to a suitable vegetative form such as unicellular yeast or filamentous mycelium for the survival and proliferation in the host as well as to defeat cellular and physiological defences of the host. The microenvironment of the pathogen triggers different biochemical processes finally leading to differentiation. These biochemical processes, which correlate with morphological change from saprophytic/less virulent to pathogenic form, can be targeted for the development of novel antifungal agents. The present chapter deals with the role of differentiation in fungal pathogenesis and discusses different biochemical events as target for the antifungal strategies.

If we can solve the same problem equally well with yeasts or with human cells, common sense tells us to stick with the simpler and less expensive system.

— James Watson

Molecular Biology of the Gene Vol. I, 1987

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Acknowledgements

The antifungal programme at CSIR-NCL, Pune, is funded by Department of Biotechnology, India (grants BT/PR15003/BRB/10/893/2010 and BT/PR7442/MED/29/680/2012). EKP thanks University Grants Commission, India, and SGT acknowledges Council of Scientific and Industrial Research, India, for research fellowships.

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  1. Biochemical Sciences Division, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pashan, 411008, Pune, India

    E. K. Pathan, S. G. Tupe & M. V. Deshpande

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  1. E. K. Pathan
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  2. S. G. Tupe
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  3. M. V. Deshpande
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Correspondence to M. V. Deshpande .

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  1. Biological Sciences and Engineering, Netaji Subhas Institute of Technology (University of Delhi), New Delhi, India

    Tulasi Satyanarayana

  2. TERI-Deakin Nano-Biotechnology Centre, The Energy and Resources Institute (TERI), New Delhi, India

    Sunil K. Deshmukh

  3. Department of Biotechnology, Barkatullah University, Bhopal, Madhya Pradesh, India

    B.N. Johri

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Pathan, E.K., Tupe, S.G., Deshpande, M.V. (2017). Fungal Differentiation: A Model Phenomenon to Screen Antifungal Drugs. In: Satyanarayana, T., Deshmukh, S., Johri, B. (eds) Developments in Fungal Biology and Applied Mycology. Springer, Singapore. https://doi.org/10.1007/978-981-10-4768-8_12

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