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Oligopeptides for Cancer and Other Biomedical Sensing Applications

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Next Generation Point-of-care Biomedical Sensors Technologies for Cancer Diagnosis

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Abstract

Sensitive and specific detection of biomarkers is a constant demand in biomedical sensing applications. Over decades, the detection of biomarkers (e.g. AFP, CEA, and PSA, etc.) in the clinical sites and research institutes mainly relied on immunoassays, where the antibodies were employed as molecular recognizing components. However, the antibodies are susceptible to temperature, and the storage of the antibodies is challenging especially in resource-limited regions. Besides, the production of antibodies is tedious, and the batch-to-batch variation is also a concern. To overcome these limitations, oligopeptides are promising candidates to replace antibodies as molecular receptors due to their abilities in molecular recognizing and the flexibility in sequence designing. In this chapter, we first introduced the screening approaches to obtain the oligopeptide sequence possessing the highest binding affinity to the target molecules. Next, we briefly reviewed the recent applications of oligopeptides for in vitro detection of protein biomarkers, tumor cells, and proteases, respectively. These advances of oligopeptides for biomedical sensing applications shed light on the next generation point-of-care biomedical sensors technologies for cancer diagnosis.

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Abbreviations

5-FAM:

5-Carboxyfluorescein

AFP:

Alpha-fetoprotein

BHQ-1:

Black hole quencher-1

BBI:

Bowman–Birk inhibitor

CEA:

Carcinoembryonic antigen

CT:

Computed tomography

CTC:

Circulating tumor cells

ctDNA:

Circulating tumor DNA

EGFR:

Epidermal growth factor receptor

ELISA:

Enzyme-linked immunosorbent assay

EphA2:

Ephrin type-A receptor 2

EphB4:

Ephrin type-B receptor 4

EpCAM:

Epithelial cell adhesion molecule

Fmoc:

N-Fluorenyl-9-methoxycarbonyl

HER2:

Human epidermal growth factor receptor 2

HIV-1:

Human immunodeficiency virus type 1

HPS:

Hexaphenylsilole

hCG:

Human chorionic gonadotropin

IL-6:

Interleukin 6

MRI:

Magnetic resonance imaging

PET:

Positron emission tomography

PSA:

Prostate-specific antigen

QCM:

Quartz crystal microbalance

RT-PCR:

Reverse transcription polymerase chain reaction

RIV:

Restriction of intramolecular vibration

RIR:

Restriction of intramolecular rotation

SPR:

Surface plasmon resonance

TAMRA:

Carboxytetramethylrhodamine

TPE:

Tetraphenylethene

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Acknowledgments

We would like to thank http://muchong.com/ in gathering the relevant literature which are not accessible from the author’s affiliation.

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Authors and Affiliations

  1. College of Materials Science and Engineering, Beijing University of Chemical Technology, 15 North 3rd Ring Road East, Beijing, 100029, China

    Xiaokang Ding

  2. Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore, 117585, Singapore

    Kun-Lin Yang

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Correspondence to Kun-Lin Yang .

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Editors and Affiliations

  1. Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam, India

    Pranjal Chandra

  2. Institute of Materials Research and Engineering, A*STAR 2 Fusionopolis Way, Singapore, Singapore

    Yen Nee Tan

  3. Electron and Ion Microscopy Group, CSIR- National Physical Laboratory, New Delhi, India

    Surinder P. Singh

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Ding, X., Yang, KL. (2017). Oligopeptides for Cancer and Other Biomedical Sensing Applications. In: Chandra, P., Tan, Y., Singh, S. (eds) Next Generation Point-of-care Biomedical Sensors Technologies for Cancer Diagnosis. Springer, Singapore. https://doi.org/10.1007/978-981-10-4726-8_12

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