Advertisement

Oxidative Stress-Related MicroRNAs as Diagnostic Markers: A Newer Insight in Diagnostics

  • Shashank Kumar
  • Abhay K. PandeyEmail author
Chapter

Abstract

Despite rapid strides in the medical and technological fields during the last four decades including the development of nucleic acid and protein-based biomarkers, the mortality still remains a burning problem because of the delayed diagnosis of many diseases. This is particularly ascribed to the lower specificity and sensitivity of the methods used for diagnosis. The compelling situation has shifted the focus of expression biology toward identification and development of sensitive and specific markers for diagnosis and prognosis of different diseases by using microRNAs (miRNAs). miRNAs are short noncoding RNAs of 18–25 nucleotides. In mammals and multicellular organisms, they play significant role in nearly all biological pathways. Next-generation sequencing techniques have played role in discovery of noncoding RNA molecules. As compared to total protein coding sequences, large numbers of noncoding RNAs exist which are key to many new discoveries related to biological phenomena and pathologies. Noncoding RNA family in humans consists of about 1400 miRNAs. Their functional significance has been shown in developmental and pathological processes. miRNAs can be easily detected in tissue samples and body fluid of the patients. Hence, miRNAs could act as potential biomarker candidates. miRNA molecules have already made their way to clinical medicine as biomarkers for diagnosis and prognosis of diseases as well as therapeutic targets for treatment. Redox imbalance leads to oxidative stress which is associated with various diseases. Accumulated evidence suggests that oxidative stress stimulates production of several miRNAs which area known as oxidative stress-responsive miRNAs. They further play a role in connecting the dysregulated antioxidant defense system with imbalanced redox state. The present chapter summarizes recent findings on diagnostic and prognostic ability of oxidative stress-responsive miRNAs. In addition, the role of miRNAs in cancer has also been discussed. Studies on functional and regulatory aspects of oxidative stress-associated miRNAs will provide new direction to discovery of novel diagnostic and prognostic biomarkers.

Notes

Acknowledgment

SK acknowledges Central University of Punjab, Bathinda, for providing necessary infrastructure facility and financial support in the form of Research Seed Money Grant GP:25. AKP also acknowledges SAP and DST-FIST facilities of the Biochemistry Department of the University of Allahabad, Allahabad, India.

References

  1. Bertoli G, Cava C, Castiglioni I. MicroRNAs: new biomarkers for diagnosis, prognosis, therapy prediction and therapeutic tools for breast cancer. Theranostics. 2015;5:1122–43.CrossRefPubMedPubMedCentralGoogle Scholar
  2. Bertoli G, Cava C, Castiglioni I. MicroRNAs as biomarkers for diagnosis, prognosis and theranostics in prostate cancer. Int J Mol Sci. 2016;17:421. doi: 10.3390/ijms17030421.CrossRefPubMedPubMedCentralGoogle Scholar
  3. Coppedè F, Migliore L. DNA repair in premature aging disorders and neurodegeneration. Curr Aging Sci. 2010;3:3–19.CrossRefPubMedGoogle Scholar
  4. Corsini LR, Bronte G, Terrasi M, Amodeo V, Fanale D, Fiorentino E, Cicero G, Bazan V, Russo A. The role of microRNAs in cancer: diagnostic and prognostic biomarkers and targets of therapies. Expert Opin Ther Targets. 2012;16:S103–9.CrossRefPubMedGoogle Scholar
  5. Czech B, Hannon GJ. Small RNA sorting: matchmaking for Argonautes. Nat Rev Genet. 2011;12:19–31.CrossRefPubMedGoogle Scholar
  6. Fanjul-Fernandez M, Folgueras AR, Cabrera S, Lopez-Otin C. Matrix metalloproteinases: evolution, gene regulation and functional analysis in mouse models. Biochim Biophys Acta-Mol Cell Res. 2010;1803:3–19.CrossRefGoogle Scholar
  7. Felicetti F, Errico MC, Bottero L, Segnalini P, Stoppacciaro A, Biffoni M, Felli N, Mattia G, Petrini M, Colombo MP, Peschle C, Care A. The promyelocytic leukemia zinc finger-microRNA-221/−222 pathway controls melanoma progression through multiple oncogenic mechanisms. Cancer Res. 2008;68:2745–54.CrossRefPubMedGoogle Scholar
  8. Feng B, Chen S, George B, Feng Q, Chakrabarti S. miR133a regulates cardiomyocyte hypertrophy in diabetes. Diabetes Metab Res Rev. 2010;26:40–9.CrossRefPubMedGoogle Scholar
  9. Feng B, Ruiz MA, Chakrabarti S. Oxidative-stress-induced epigenetic changes in chronic diabetic complications. Physiol Pharmacol. 2013;91:213–20. dx.doi.org/10.1139/cjpp-2012-0251CrossRefGoogle Scholar
  10. He ML, Luo MXM, Lin MC, Kung HF. MicroRNAs: potential diagnostic markers and therapeutic targets for EBV-associated nasopharyngeal carcinoma. Biochim Biophys Acta-Rev Cancer. 2012;1825:1–10.CrossRefGoogle Scholar
  11. Huang SL, Wu SQ, Ding J, Lin J, Wei L, Gu JR, He XH. MicroRNA-181a modulates gene expression of zinc finger family members by directly targeting their coding regions. Nucleic Acids Res. 2010;38:7211–8.CrossRefPubMedPubMedCentralGoogle Scholar
  12. Jansson MD, Lund AH. MicroRNA and cancer. Mol Oncol. 2012;6:590–610.CrossRefPubMedPubMedCentralGoogle Scholar
  13. Kato M, Zhang J, Wang M, Lanting L, Yuan H, Rossi JJ. MicroRNA-192 in diabetic kidney glomeruli and its function in TGF-beta induced collagen expression via inhibition of E-box repressors. Proc Natl Acad Sci U S A. 2007;104:3432–7.CrossRefPubMedPubMedCentralGoogle Scholar
  14. Kumar S, Pandey AK. Free radicals: health implications and their mitigation by herbals. Br J Med Med Res. 2015;7:438–57. doi: 10.9734/BJMMR/2015/16284.CrossRefGoogle Scholar
  15. Lim LP, Lau NC, Garrett-Engele P, Grimson A, Schelter JM, Castle J, Bartel DP, Linsley PS, Johnson JM. Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature. 2005;433:769–73.CrossRefPubMedGoogle Scholar
  16. Liu XQ, Wang C, Chen ZJ, Jin Y, Wang Y, Kolokythas A, Dai Y, Zhou XF. MicroRNA-138 suppresses epithelial-mesenchymal transition in squamous cell carcinoma cell lines. Biochem J. 2011;440:23–31.CrossRefPubMedPubMedCentralGoogle Scholar
  17. Magenta A, Cencioni C, Fasanaro P, Zaccagnini G, Greco S, Sarra-Ferraris G, Antonini A, Martelli F, Capogrossi MC. miR-200c is upregulated by oxidative stress and induces endothelial cell apoptosis and senescence via ZEB1 inhibition. Cell Death Differ. 2011;18:1628–39.CrossRefPubMedPubMedCentralGoogle Scholar
  18. Magenta A, Greco S, Gaetano C, Martelli F. Oxidative stress and microRNAs in vascular diseases. Int J Mol Sci. 2013;14:17319–46.CrossRefPubMedPubMedCentralGoogle Scholar
  19. Mateescu B, Batista L, Cardon M, Gruosso T, de Feraudy Y, Mariani O, Nicolas A, Meyniel JP, Cottu P, Sastre-Garau X. miR-141 and miR-200a act on ovarian tumorigenesis by controlling oxidative stress response. Nat Med. 2011;17:1627–35.CrossRefPubMedGoogle Scholar
  20. Menghini R, Casagrande V, Cardellini M, Martelli E, Terrinoni A, Amati F, Vasa-Nicotera M, Ippoliti A, Novelli G, Melino G. MicroRNA 217 modulates endothelial cell senescence via silent information regulator. Circulation. 2001;120:1524–32.CrossRefGoogle Scholar
  21. Narasimhan M, Riar AK, Rathinam ML, Vedpathak D, Henderson G, Mahimainathan L. Hydrogen peroxide responsive miR153 targets Nrf2/ARE cytoprotection in paraquat induced dopaminergic neurotoxicity. Toxicol Lett. 2014;228:179–91.CrossRefPubMedPubMedCentralGoogle Scholar
  22. Pal MK, Jaiswar SP, Dwivedi VN, Tripathi AK, Dwivedi A, Sankhwar P. MicroRNA: a new and promising potential biomarker for diagnosis and prognosis of ovarian cancer. Cancer Biol Med. 2015;12:328–41.PubMedPubMedCentralGoogle Scholar
  23. Pekarik V, Gumulec J, Masarik M, Kizek R, Adam V. Prostate cancer, miRNAs, metallothioneins and resistance to cytostatic drugs. Curr Med Chem. 2013;20:534–44.PubMedGoogle Scholar
  24. Prendecki M, Dorszewska J. The role of microRNA in the pathogenesis and diagnosis of neurodegenerative diseases. Austin Alzheimers J Parkinsons Dis. 2014;1:1–10.Google Scholar
  25. Varga ZV, Kupai K, Szűcs G, Gáspár R, Pálóczi J, Faragó N, Zvara A, Puskás LG, Rázga Z, Tiszlavicz L, Bencsik P, Görbe A, Csonka C, Ferdinandy P, Csont T. MicroRNA-25-dependent up-regulation of NADPH oxidase 4 (NOX4) mediates hypercholesterolemia-induced oxidative/nitrative stress and subsequent dysfunction in the heart. J Mol Cell Cardiol. 2013;62:111–21.CrossRefPubMedGoogle Scholar
  26. Von-Dessauer B, Bongain J, Molina V, Quilodrán J, Castillo R, Rodrigo R. Oxidative stress as a novel target in pediatric sepsis management. J Crit Care. 2011;26:103.e1–7.CrossRefGoogle Scholar
  27. Wang Q, Wang Y, Minto AW, Wang J, Shi Q, Li X. MicroRNA-377 is up-regulated and can lead to increased fibronectin production in diabetic nephropathy. FASEB J. 2008;22:4126–35.CrossRefPubMedPubMedCentralGoogle Scholar
  28. Wang Z, Ruan Z, Mao Y, Dong W, Zhang Y, Yin N, Jiang L. miR-27a is up regulated and promotes inflammatory response in sepsis. Cell Immunol. 2014;290:190–5.CrossRefPubMedGoogle Scholar
  29. Yao L, Liu Z, Zhu J, Li B, Cha C, Tian Y. Clinical evaluation of circulating microRNA-25 level change in sepsis and its potential relationship with oxidative stress. Int J Clin Exp Pathol. 2015;8:7675–84.PubMedPubMedCentralGoogle Scholar
  30. Yildirim SS, Akman D, Catalucci D, Turan B. Relationship between downregulation of miRNAs and increase of oxidative stress in the development of diabetic cardiac dysfunction: junctin as a target protein of mir-1. Cell Biochem Biophys. 2013;67:1397–408.CrossRefPubMedGoogle Scholar
  31. Yu XY, Song YH, Geng YJ, Lin QX, Shan ZX, Lin SG. Glucose induces apoptosis of cardiomyocytes via microRNA-1 and IGF-1. Biochem Biophys Res Commun. 2008;376:548–52.CrossRefPubMedGoogle Scholar
  32. Zhang B, Sun S, Shen L, Zu X. DNA methylation in the rat livers induced by low dosage isoniazid treatment. Environ Toxicol Pharmacol. 2011;32:486–90.CrossRefPubMedGoogle Scholar
  33. Zhou J, Chaudhry H, Zhong Y, Ali MM, Perkins LA, Owens WB, Morales JE, McGuire FR, Zumbrun EE, Zhang J, Nagarkatti PS, Nagarkatti M. Dysregulation in microRNA expression in peripheral blood mononuclear cells of sepsis patients is associated with immunopathology. Cytokine. 2015;71:89–100.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. 2017

Authors and Affiliations

  1. 1.Centre for Biochemistry and Microbial SciencesCentral University of PunjabBathindaIndia
  2. 2.Department of BiochemistryUniversity of AllahabadAllahabadIndia

Personalised recommendations