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Etiology of Chronic Pancreatitis

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Abstract

Alcohol is one of the factors frequently associated with chronic pancreatitis; its frequency is lower than that previously reported and heavy alcohol consumption and smoking habit are two independent risk factors for this disease. Autoimmune pancreatitis accounts for 2–4% of all forms of chronic pancreatitis, but this frequency will probably increase over the next few years. There has also been a rise in idiopathic chronic pancreatitis around the world. Despite the progress made to date regarding the discovery of the hereditary forms of chronic pancreatitis and the detection of autoimmune pancreatitis, there are more inaccuracies in identifying the factors associated with chronic pancreatitis.

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References

  • Abraham SC, Wilentz RE, Yeo CJ, Sohn TA, Cameron JL, Boitnott JK, Hruban RH. Pancreaticoduodenectomy (Whipple resections) in patients without malignancy: are they all ‘chronic pancreatitis’? Am J Surg Pathol. 2003;27(1):110–20.

    Article  PubMed  Google Scholar 

  • Ammann RW, Akovbiantz A, Largiader F, Schueler G. Course and outcome of chronic pancreatitis. Longitudinal study of a mixed medical-surgical series of 245 patients. Gastroenterology. 1984;86:820–8.

    CAS  PubMed  Google Scholar 

  • Balakrishnan V, Unnikrishnan AG, Thomas V, Choudhuri G, Veeraraju P, Singh SP, et al. Chronic pancreatitis. A prospective nationwide study of 1,086 Subjects from India. JOP. 2008;9:593–600.

    PubMed  Google Scholar 

  • Banks PA. Epidemiology, natural history, and predictors of disease outcome in acute and chronic pancreatitis. Gastrointest Endosc. 2002;56:S226–30.

    Article  PubMed  Google Scholar 

  • Bhatia E, Durie P, Zielenski J, Lam D, Sikora SS, Choudhuri G, Tsui LC. Mutations in the cystic fibrosis transmembrane regulator gene in patients with tropical calcific pancreatitis. Am J Gastroenterol. 2000;95:3658–9.

    Article  CAS  PubMed  Google Scholar 

  • Bhatia E, Choudhuri G, Sikora SS, Landt O, Kage A, Becker M, Witt H. Tropical calcific pancreatitis: strong association with SPINK1 trypsin inhibitor mutations. Gastroenterology. 2002;123:1020–5.

    Article  CAS  PubMed  Google Scholar 

  • Catalano MF, Sahai A, Levy M, et al. EUS-based criteria for the diagnosis of chronic pancreatitis: the Rosemont classification. Gastrointest Endosc. 2009;69:1251–61.

    Article  PubMed  Google Scholar 

  • Cavallini G, Frulloni L, Pederzoli P, Talamini G, Bovo P, Bassi C, et al. Long-term follow-up of patients with chronic pancreatitis in Italy. Scand J Gastroenterol. 1998;33:880–9.

    CAS  PubMed  Google Scholar 

  • Chari ST, Mohan V, Jayanthi V, Snehalatha C, Malathi S, Viswanathan M, Madanagopalan N. Comparative study of the clinical profiles of alcoholic chronic pancreatitis and tropical chronic pancreatitis in Tamil Nadu, South India. Pancreas. 1992;7:52–8.

    Article  CAS  PubMed  Google Scholar 

  • Coté GA, Yadav D, Slivka A, Hawes RH, Anderson MA, Burton FR, Brand RE, Banks PA, Lewis MD, Disario JA, Gardner TB, Gelrud A, Amann ST, Baillie J, Money ME, O’Connell M, Whitcomb DC, Sherman S, North American Pancreatitis Study Group. Alcohol and smoking as risk factors in an epidemiology study of patients with chronic pancreatitis. Clin Gastroenterol Hepatol. 2011;9:266–73.

    Google Scholar 

  • Dani R, Mott CB, Guarita DR, Nogueira CE. Epidemiology and etiology of chronic pancreatitis in Brazil: a tale of two cities. Pancreas. 1990;5:474–8.

    Article  CAS  PubMed  Google Scholar 

  • Das SK, Balakrishnan V, Vasudevan DM. Alcohol: its health and social impact in India. Natl Med J India. 2006;19:94–9.

    PubMed  Google Scholar 

  • Díte P, Starý K, Novotný I, Precechtelová M, Dolina J, Lata J, Zboril V. Incidence of chronic pancreatitis in the Czech Republic. Eur J Gastroenterol Hepatol. 2001;13:749–50.

    Article  PubMed  Google Scholar 

  • Durbec JP, Sarles H. Multicenter survey of the etiology of pancreatic diseases. Relationship between the relative risk of developing chronic pancreatitis and alcohol, protein and lipid consumption. Digestion. 1978;18:337–50.

    Article  CAS  PubMed  Google Scholar 

  • Dzieniszewski J, Jarosz M, Ciok J. Chronic pancreatitis in Warsaw. Mater Med Pol. 1990;22:202–4.

    CAS  PubMed  Google Scholar 

  • Fantini L, Zanini N, Fiscaletti M, Calculli L, Casadei R, Campana D, Pezzilli R. Autoimmune pancreatitis: the classification puzzle. Adv Med Sci. 2007;52:71–5.

    CAS  PubMed  Google Scholar 

  • Felderbauer P, Hoffmann P, Einwächter H, Bulut K, Ansorge N, Schmitz F, Schmidt WE. A novel mutation of the calcium sensing receptor gene is associated with chronic pancreatitis in a family with heterozygous SPINK1 mutations. BMC Gastroenterol. 2003;3:34.

    Article  PubMed  PubMed Central  Google Scholar 

  • Frulloni L, Gabbrielli A, Pezzilli R, Zerbi A, Cavestro GM, Marotta F, et al. Chronic pancreatitis: report from a multicenter Italian survey (PancroInfAISP) on 893 patients. Dig Liver Dis. 2009;41:311–7.

    Article  CAS  PubMed  Google Scholar 

  • Garg PK, Tandon RK. Survey on chronic pancreatitis in the Asia-Pacific region. J Gastroenterol Hepatol. 2004;19:998–1004.

    Article  PubMed  Google Scholar 

  • Gullo L, Costa PL, Labò G. Chronic pancreatitis in Italy. Aetiological, clinical and histological observations based on 253 cases. Rendic Gastroenterol. 1977;9:97–104.

    Google Scholar 

  • Gullo L, Barbara L, Labò G. Effect of cessation of alcohol use on the course of pancreatic dysfunction in alcoholic pancreatitis. Gastroenterology. 1988;95:1063–8.

    Article  CAS  PubMed  Google Scholar 

  • Hart PA, Zen Y, Chari ST. Recent advances in autoimmune pancreatitis. Gastroenterology. 2015;149:39–51.

    Article  CAS  PubMed  Google Scholar 

  • Hirota M, Shimosegawa T, Masamune A, Kikuta K, Kume K, Hamada S, Kanno A, Kimura K, Tsuji I, Kuriyama S. Research committee of intractable pancreatic diseases. The seventh nationwide epidemiological survey for chronic pancreatitis in Japan: clinical significance of smoking habit in Japanese patients. Pancreatology. 2014;14:490–6.

    Article  PubMed  Google Scholar 

  • Jaakkola M, Nordback I. Pancreatitis in Finland between 1970 and 1989. Gut. 1993;34:1255–60.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • James O, Agnew JE, Bouchier IA. Chronic pancreatitis in England: a changing picture. Br Med J. 1974;2:34–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Johnson CD, Hosking S. National statistics for diet, alcohol consumption, and chronic pancreatitis in England and Wales, 1960–88. Gut. 1991;32:1401–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kuroda J, Suda K, Hosokawa Y. Periacinar collagenization in patients with chronic alcoholism. Pathol Int. 1998;48:857–68.

    Article  CAS  PubMed  Google Scholar 

  • Lankisch PG, Banks PA. Pancreatitis. New York: Springer; 1998.

    Book  Google Scholar 

  • LaRusch J, Lozano-Leon A, Stello K, Moore A, Muddana V, O’Connell M, Diergaarde B, Yadav D, Whitcomb DC. The common Chymotrypsinogen C (CTRC) Variant G60G (C.180T) increases risk of chronic pancreatitis but not recurrent acute pancreatitis in a North American population. Clin Transl Gastroenterol. 2015;6:e68.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lester FT. A search for malnutrition-related diabetes mellitus among Ethiopian patients. Diabetes Care. 1993;16:187–92.

    Article  CAS  PubMed  Google Scholar 

  • Lowenfels AB, Maisonneuve P, Cavallini G, Ammann RW, Lankisch PG, Andersen JR, et al. Pancreatitis and the risk of pancreatic cancer. International Pancreatitis Study Group. N Engl J Med. 1993;328:1433–7.

    Article  CAS  PubMed  Google Scholar 

  • Lowenfels AB, Maisonneuve P, DiMagno EP, Elitsur Y, Gates LK Jr, Perrault J, Whitcomb DC. Hereditary pancreatitis and the risk of pancreatic cancer. International Hereditary Pancreatitis Study Group. J Natl Cancer Inst. 1997;89(6):442.

    Article  CAS  PubMed  Google Scholar 

  • Marks IN, Girdwood AH, Bank S, Louw JH. The prognosis of alcohol-induced calcific pancreatitis. S Afr Med J. 1980;57:640–3.

    CAS  PubMed  Google Scholar 

  • Martin E, Bedossa P. Diffuse fibrosis of the pancreas: a peculiar pattern of pancreatitis in alcoholic cirrhosis. Gastroenterol Clin Biol. 1989;13:579–84.

    CAS  PubMed  Google Scholar 

  • Mills A. Reflections on the development of health economics in low- and middle-income countries. Proc Biol Sci. 2014;281(1789):20140451.

    Article  PubMed  PubMed Central  Google Scholar 

  • Mohan V, Premalatha G, Pitchumoni CS. Tropical chronic pancreatitis: an update. J Clin Gastroenterol. 2003;36:337–46.

    Article  CAS  PubMed  Google Scholar 

  • Montalto G, Carroccio A, Soresi M, Ficano L, Notarbartolo A. Chronic pancreatitis in Sicily. Preliminary reports. Ital J Gastroenterol. 1990;22:33–5.

    CAS  PubMed  Google Scholar 

  • Morselli-Labate AM, Fantini L, Pezzilli R. Hydrogen sulfide, nitric oxide and a molecular mass 66 u substance in the exhaled breath of chronic pancreatitis patients. Pancreatology. 2007;7:497–504.

    Article  CAS  PubMed  Google Scholar 

  • O’Sullivan JN, Nobrega FT, Morlock CG, Brown AL Jr, Bartholomew LG. Acute and chronic pancreatitis in Rochester, Minnesota, 1940–1969. Gastroenterology. 1972;62:373–9.

    PubMed  Google Scholar 

  • Otsuki M. Chronic pancreatitis in Japan: epidemiology, prognosis, diagnostic criteria, and future problems. J Gastroenterol. 2003;38:315–26.

    Article  PubMed  Google Scholar 

  • Pearson RK, Longnecker DS, Chari ST, Smyrk TC, Okazaki K, Frulloni L, Cavallini G. Controversies in clinical pancreatology: autoimmune pancreatitis: does it exist. Pancreas. 2003;27:1–13.

    Article  PubMed  Google Scholar 

  • Pezzilli R. Pancreatitis. Secretin increases the diagnostic yield of MRCP. Nat Rev Gastroenterol Hepatol. 2014;11:519–20.

    Article  PubMed  Google Scholar 

  • Pezzilli R. Alcohol abuse and pancreatic diseases: an overview. Recent Patents Inflamm Allergy Drug Discov. 2015;9(2):102–6.

    Article  CAS  Google Scholar 

  • Pezzilli R, Pagano N. Pathophysiology of autoimmune pancreatitis. World J Gastrointest Pathophysiol. 2014;5(1):11–7.

    Article  PubMed  PubMed Central  Google Scholar 

  • Pezzilli R, Morselli-Labate AM, Mantovani V, Romboli E, Selva P, Migliori M, Corinaldesi R, Gullo L. Mutations of the CFTR gene in pancreatic disease. Pancreas. 2003;27:332–6.

    Article  CAS  PubMed  Google Scholar 

  • Pezzilli R, Morselli-Labate AM, Fantini L, Campana D, Corinaldesi R. Assessment of the quality of life in chronic pancreatitis using Sf-12 and EORTC Qlq-C30 questionnaires. Dig Liver Dis. 2007;39:1077–86.

    Article  CAS  PubMed  Google Scholar 

  • Pezzilli R, Imbrogno A, Fabbri D. Autoimmune pancreatitis management: reflections on the past decade and the decade to come. Expert Rev Clin Immunol. 2012;8(2):115–7.

    Article  PubMed  Google Scholar 

  • Raimondi S, Lowenfels AB, Morselli-Labate AM, Maisonneuve P, Pezzilli R. Pancreatic cancer in chronic pancreatitis; aetiology, incidence, and early detection. Best Pract Res Clin Gastroenterol. 2010;24:349–58.

    Article  PubMed  Google Scholar 

  • Rajesh G, Girish BN, Panicker S, Balakrishnan V. Time trends in the etiology of chronic pancreatitis in South India. Trop Gastroenterol. 2014;35(3):164–7.

    Article  PubMed  Google Scholar 

  • Rommens JM, Iannuzzi MC, Kerem B, Drumm ML, Melmer G, Dean M, et al. Identification of the cystic fibrosis gene: chromosome walking and jumping. Science. 1989;245:1059–65.

    Article  CAS  PubMed  Google Scholar 

  • Ryu JK, Lee JK, Kim YT, Lee DK, Seo DW, Lee KT, et al. Clinical features of chronic pancreatitis in Korea: a multicenter nationwide study. Digestion. 2005;72:207–11.

    Article  PubMed  Google Scholar 

  • Sarles H, Cros RC, Bidart JM. A multicenter inquiry into the etiology of pancreatic diseases. Digestion. 1979;19:110–25.

    Article  CAS  PubMed  Google Scholar 

  • Schneider A, Suman A, Rossi L, Barmada MM, Beglinger C, Parvin S, et al. SPINK1/PSTI mutations are associated with tropical pancreatitis and type II diabetes mellitus in Bangladesh. Gastroenterology. 2002;123:1026–30.

    Article  CAS  PubMed  Google Scholar 

  • Suda K, Takase M, Takei K, Nakamura T, Akai J, Nakamura T. Histopathologic study of coexistent pathologic states in pancreatic fibrosis in patients with chronic alcohol abuse: two distinct pathologic fibrosis entities with different mechanisms. Pancreas. 1996;12:369–72.

    Article  CAS  PubMed  Google Scholar 

  • Talukdar R, Saikia N, Singal DK, Tandon R. Chronic pancreatitis: evolving paradigms. Pancreatology. 2006;6:440–9.

    Article  CAS  PubMed  Google Scholar 

  • Tandon RK, Sato N, Garg PK, Consensus Study Group. Chronic pancreatitis: Asia-Pacific consensus report. J Gastroenterol Hepatol. 2002;17:508–18.

    Article  PubMed  Google Scholar 

  • Thorsgaard Pedersen N, Nyboe Andersen B, Pedersen G, Worning H. Chronic pancreatitis in Copenhagen. A retrospective study of 64 consecutive patients. Scand J Gastroenterol. 1982;17:925–31.

    Article  CAS  PubMed  Google Scholar 

  • Whitcomb DC, Gorry MC, Preston RA, Furey W, Sossenheimer MJ, Ulrich CD, et al. Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene. Nat Genet. 1996;14:141–5.

    Article  CAS  PubMed  Google Scholar 

  • WHO. WHO global status report on alcohol 2004. World Health Organization. Department of Mental Health and Substance Abuse, Geneva 2004.

    Google Scholar 

  • Witt H, Luck W, Hennies HC, Classen M, Kage A, Lass U, Landt O, Becker M. Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis. Nat Genet. 2000;25:213–6.

    Article  CAS  PubMed  Google Scholar 

  • Yadav D, Hawes RH, Brand RE, Anderson MA, Money ME, Banks PA, Bishop MD, Baillie J, Sherman S, DiSario J, Burton FR, Gardner TB, Amann ST, Gelrud A, Lawrence C, Elinoff B, Greer JB, O’Connell M, Barmada MM, Slivka A, Whitcomb DC, North American Pancreatic Study Group. Alcohol consumption, cigarette smoking, and the risk of recurrent acute and chronic pancreatitis. Arch Intern Med. 2009;169:1035–45.

    Article  PubMed  Google Scholar 

  • Zuidema PJ. Cirrhosis and disseminated calcification of the pancreas in patients with malnutrition. Trop Geogr Med. 1959;11:70–4.

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Digestive System, Sant’Orsola-Malpighi Hospital, Via Massarenti 9, 40138, Bologna, Italy

    Raffaele Pezzilli

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  1. Raffaele Pezzilli
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Correspondence to Raffaele Pezzilli .

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Editors and Affiliations

  1. Department of Gastroenterology, Changhai Hospital, Shanghai, China

    Zhao-Shen Li

  2. Changhai Hospital, Department of Gastroenterology, Shanghai, China

    Zhuan Liao

  3. INSERM, Brest, France

    Jian-Min Chen

  4. INSERM UMR 1078, Brest, France

    Claude Férec

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Pezzilli, R. (2017). Etiology of Chronic Pancreatitis. In: Li, ZS., Liao, Z., Chen, JM., Férec, C. (eds) Chronic Pancreatitis. Springer, Singapore. https://doi.org/10.1007/978-981-10-4515-8_4

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  • DOI: https://doi.org/10.1007/978-981-10-4515-8_4

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