Chronic Pancreatitis and Pancreatic Cancer
Pancreatic cancer is one of the deadliest diseases and the current therapeutic maneuvers have little impact on disease course and outcome. While understanding the cellular and molecular mechanisms underlying pancreatic cancer pathogenesis has long been one of the major focuses of cancer research, recent studies have unprecedentedly uncovered molecular and cellular bases for the sequential transformation from normal pancreatic epithelium to invasive pancreatic cancer. However, targeted therapy against genetic events accompanying this roadmap failed to generate benefits in clinic. Recent studies have identified that chronic inflammation in microenvironment is one of the critical factors initiating and driving pancreatic carcinogenesis. Targeted manipulation of certain components in tumor microenvironment has shown therapeutic promises in clinic. In this review, we will summarize current knowledge on the roles of inflammation and chronic pancreatitis in pancreatic cancer initiation and progression, and its clinic significance in early detection and intervention of pancreatic cancer.
Funding: Supported in part by grants R01-CA129956, R01-CA148954, R01CA152309 and R01CA172233, and R01CA195651; and grant No.81402017 from NSFC of China.
Conflicts of Interest: The authors disclose no conflicts.
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