A Short History of Research into Chronic Pancreatitis



Chronic pancreatitis (CP) is an irreversible condition of the pancreas characterized by chronic progressive pancreatic inflammation and fibrosis, resulting in the failure of exocrine and endocrine function. Of all pancreatic diseases, CP is the most complicated, a condition with increasing incidence but a relatively short research history. Because of its uncertain and complicated pathogenesis, there is no effective diagnostic test or treatment measure. Thus, CP still exerts an adverse impact on the quality of life of those affected. Herein, we briefly review the history of basic and clinical research into chronic pancreatitis.


Chronic pancreatitis Etiology Pathogenesis Diagnosis Treatment Research history 


  1. Ammann RW. Zürich workshop on alcoholic chronic pancreatitis. Int J Pancreatol. 1998;23:81–2.PubMedGoogle Scholar
  2. Buchler MW, Martignoni ME, Friess H, et al. A proposal for a new clinical classification of chronic pancreatitis. BMC Gastroenterol. 2009;9:93.CrossRefPubMedPubMedCentralGoogle Scholar
  3. Cawley T. A singular case of diabetes, consisting entirely in the quantity of the urine with an enquiry into the different theories of that disease. Lond Med J. 1788;9:286.PubMedPubMedCentralGoogle Scholar
  4. Chaussy C, Brendel W, Schmiedt E. Extracorporeally induced destruction of kidney stones by shock waves. Lancet. 1980;2:1265–8.CrossRefPubMedGoogle Scholar
  5. Chiari H. Ueber Selbstverdauung des menschlichen Pankreas. Zeitschrift für Heilkunde. 1896;17:69–96.Google Scholar
  6. Classen M, Demling L. Endoscopic sphincterotomy of the papilla of Vater and extraction of stones from the choledochal duct (author’s transl). Dtsch Med Wochenschr. 1974;99:496–7.CrossRefPubMedGoogle Scholar
  7. Cohn JA, Friedman KJ, Noone PG, et al. Relation between mutations of the cystic fibrosis gene and idiopathic pancreatitis. N Engl J Med. 1998;339:653–8.CrossRefPubMedGoogle Scholar
  8. Comfort M, Steinberg A. Pedigree of a family with hereditary chronic replasing pancreatitis. Gastroenterology. 1952;21:54–63.PubMedGoogle Scholar
  9. Comfort M, Gambill E, Baggenstoss AH. Chronic relapsing pancreatitis: a study of twenty-nine cases without associated disease of the biliary or gasto-intestinal tract. Gastroenterology. 1946;6:238–76.Google Scholar
  10. DiMagno EP. A short, eclectic history of exocrine pancreatic insufficiency and chronic pancreatitis. Gastroenterology. 1993;104:1255–62.CrossRefPubMedGoogle Scholar
  11. DiMagno EP, Buxton JL, Regan PT, et al. Ultrasonic endoscope. Lancet. 1980;1:629–31.CrossRefPubMedGoogle Scholar
  12. Duval MK Jr. Caudal pancreatico-jejunostomy for chronic relapsing pancreatitis. Ann Surg. 1954;140:775–85.CrossRefPubMedGoogle Scholar
  13. Fitzgerald PJ. Medical anecdotes concerning some diseases of the pancreas. In: Fitzgerald PJ, Morrison AB, editors. The pancreas. Baltimore: Williams and Wilkins; 1980. p. 1–29.Google Scholar
  14. Friedrich N. Diseases of the pancreas. In:Cyclopedia of the practice of medicine, vol. 8. New York: William Wood; 1878. p. 599.Google Scholar
  15. Hamano H, Kawa S, Horiuchi A, et al. High serum IgG4 concentrations in patients with sclerosing pancreatitis. N Engl J Med. 2001;344:732–8.CrossRefPubMedGoogle Scholar
  16. Hess AF. A consideration of the pancreas and its ducts in congenital obliteration of the bile-ducts. Arch Intern Med. 1912;1:37–44.CrossRefGoogle Scholar
  17. Kawai K, Akasaka Y, Murakami K, et al. Endoscopic sphincterotomy of the ampulla of Vater. Gastrointest Endosc. 1974;20:148–51.CrossRefPubMedGoogle Scholar
  18. Masson E, Chen JM, Scotet V, et al. Association of rare chymotrypsinogen C (CTRC) gene variations in patients with idiopathic chronic pancreatitis. Hum Genet. 2008;123:83–91.CrossRefPubMedGoogle Scholar
  19. McCune WS, Shorb PE, Moscovitz H. Endoscopic cannulation of the ampulla of Vater: a preliminary report. Ann Surg. 1968;167:752–6.CrossRefPubMedPubMedCentralGoogle Scholar
  20. Modlin IM. The paradox of the pancreas: from wirsüng to whipple. Hannover: Politzki Print Productions; 2003.Google Scholar
  21. Narendranathan M, Sharma KN, Sosamma PI. Serum rhodanese in goitre and calcific pancreatitis of tropics. J Assoc Physicians India. 1989;37:648–9.PubMedGoogle Scholar
  22. Rosendahl J, Witt H, Szmola R, et al. Chymotrypsin C (CTRC) variants that diminish activity or secretion are associated with chronic pancreatitis. Nat Genet. 2008;40:78–82.CrossRefPubMedGoogle Scholar
  23. Sachs M. Study of the pancreas and its inflammatory diseases from the 16th–19th century. Zentralbl Chir. 1993;118:702–11.PubMedGoogle Scholar
  24. Sauerbruch T, Holl J, Sackmann M, et al. Disintegration of a pancreatic duct stone with extracorporeal shock waves in a patient with chronic pancreatitis. Endoscopy. 1987;19:207–8.CrossRefPubMedGoogle Scholar
  25. Seigel J. Evalution and treatment of acquired and congenital pancreatic disorders: endoscopic dilatation and insertion of endoprostheses. Am J Gastroenterol. 1983;78:A696.Google Scholar
  26. Sharer N, Schwarz M, Malone G, et al. Mutations of the cystic fibrosis gene in patients with chronic pancreatitis. N Engl J Med. 1998;339:645–52.CrossRefPubMedGoogle Scholar
  27. Singer C. A short history of anatomy from the greeks to harvey. New York: Dover Publications; 1957. p. 111.Google Scholar
  28. Vilmann P, Hancke S, Henriksen FW, et al. Endosonographically-guided fine needle aspiration biopsy of malignant lesions in the upper gastrointestinal tract. Endoscopy. 1993;25:523–7.CrossRefPubMedGoogle Scholar
  29. Whipple AO, Parsons WB, Mullins CR. Treatment of carcinoma of the ampulla of Vater. Ann Surg. 1935;102:763–79.CrossRefPubMedPubMedCentralGoogle Scholar
  30. Whitcomb DC, Gorry MC, Preston RA, et al. Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene. Nat Genet. 1996;14:141–5.CrossRefPubMedGoogle Scholar
  31. Witt H, Luck W, Hennies HC, et al. Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis. Nat Genet. 2000;25:213–6.CrossRefPubMedGoogle Scholar
  32. Yoshida K, Toki F, Takeuchi T, et al. Chronic pancreatitis caused by an autoimmune abnormality. Proposal of the concept of autoimmune pancreatitis. Dig Dis Sci. 1995;40:1561–8.CrossRefPubMedGoogle Scholar
  33. Zuideman P. Calcification and cirrhosis of the pancreas in patients with deficient nutrition. Doc Med Geograph Trop Amsterdam. 1955;5:229–31.Google Scholar

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© Springer Nature Singapore Pte Ltd. and Shanghai Scientific and Technical Publishers 2017

Authors and Affiliations

  1. 1.Department of GastroenterologyChanghai Hospital, the Second Military Medical UniversityShanghaiChina
  2. 2.Shanghai Institute of Pancreatic DiseasesShanghaiChina
  3. 3.Institute of Medical Genetics, School of MedicineCardiff UniversityCardiffUK
  4. 4.Institut National de la Santé et de la Recherche Médicale (INSERM)BrestFrance
  5. 5.Etablissement Français du Sang (EFS)—BretagneBrestFrance
  6. 6.Faculté de Médecine et des Sciences de la SantéUniversité de Bretagne Occidentale (UBO)BrestFrance

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