Abstract
Lung injury can be diagnosed as drug induced when it develops during the time span of drug intake, when it is a possible side effect of the drug, and after excluding other causes. Even if a new lung injury appears immediately after drug administration, it does not necessarily mean that it is drug induced. Some considerations could be pneumonia caused by an opportunistic infection, exacerbation of underlying disease, or other unrelated diseases. The differential diagnoses of drug-induced lung injury are described in this chapter.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Kubo K, Azuma A, Kanazawa M, Kameda H, Kusumoto M, Genma A, Saijo Y, Sakai F, Sugiyama Y, Tatsumi K, Dohi M, Tokuda H, Hashimoto S, Hattori N, Hanaoka M, Fukuda Y, Japanese Respiratory Society Committee for formulation of Consensus statement for the diagnosis and treatment of drug-induced lung injuries. Consensus statement for the diagnosis and treatment of drug-induced lung injuries. Respir Invest. 2013;51(4):260–77.
Yokoyama A. Approach to the diagnosis of drug-induced lung diseases. Nihon Naika Gakkai Zasshi. 2007;96(6):1097–103.
Japanese Respiratory Society Committee for formulation of the guide for the Biological agents and respiratory diseases: Guide for the medical treatment. Biological agents and respiratory diseases: Guide for the medical treatment. 2014. http://www.jrs.or.jp/modules/guidelines/index.php?content_id=69.
Hirata S, Hattori N, Kumagai K, Haruta Y, Yokoyama A, Kohno N. Lymphocyte transformation test is not helpful for the diagnosis of methotrexate-induced pneumonitis in patients with rheumatoid arthritis. Clin Chim Acta. 2009;407(1–2):25–9.
Hyzy R, Huang S, Myers J, Flaherty K, Martinez F. Acute exacerbation of idiopathic pulmonary fibrosis. Chest. 2007;132(5):1652–8.
Sato T, Teramukai S, Kondo H, Watanabe A, Ebina M, Kishi K, Fujii Y, Mitsudomi T, Yoshimura M, Maniwa T, Suzuki K, Kataoka K, Sugiyama Y, Kondo T, Date H, Japanese Association for Chest Surgery. Impact and predictors of acute exacerbation of interstitial lung diseases after pulmonary resection for lung cancer. J Thorac Cardiovasc Surg. 2014;147(5):1604–11.
Azuma A, Kudo S. Drug-induced pneumonia and Japanese. Nihon Naika Gakkai Zasshi. 2007;96(6):1077–82.
Kenmotsu H, Naito T, Kimura M, Ono A, Shukuya T, Nakamura Y, Tsuya A, Kaira K, Murakami H, Takahashi T, Endo M, Yamamoto N. The risk of cytotoxic chemotherapy-related exacerbation of interstitial lung disease with lung cancer. J Thorac Oncol. 2011;6(7):1242–6.
Niho S, Goto K, Yoh K, Kim YH, Ohmatsu H, Kubota K, Saijo N, Nishiwaki Y. Interstitial shadow on chest CT is associated with the onset of interstitial lung disease caused by chemotherapeutic drugs. Jpn J Clin Oncol. 2006;36(5):269–73.
Imokawa S, Colby TV, Leslie KO, Helmers RA. Methotrexate pneumonitis: review of the literature and histopathological findings in nine patients. Eur Respir J. 2000;15(2):373–81.
Johkoh T, Müller NL, Akira M, Ichikado K, Suga M, Ando M, Yoshinaga T, Kiyama T, Mihara N, Honda O, Tomiyama N, Nakamura H. Eosinophilic lung diseases: diagnostic accuracy of thin-section CT in 111 patients. Radiology. 2000;216(3):773–80.
Poletti V, Salvucci M, Zanchini R, Molinari AL, Zuffa E, Poletti G, Zaccaria A. The lung as a target organ in patients with hematologic disorders. Haematologica. 2000;85(8):855–64.
Kameda T, Dobashi H. Rheumatoid arthritis and malignancy. Nihon Rinsho. 2016;74(6):1017–21.
Khot PD, Fredricks DN. PCR-based diagnosis of human fungal infections. Expert Rev Anti Infect Ther. 2009;7(10):1201–21.
Couturier MR, Graf EH, Griffin AT. Urine antigen tests for the diagnosis of respiratory infections: legionellosis, histoplasmosis, pneumococcal pneumonia. Clin Lab Med. 2014;34(2):219–36.
Onishi A, Sugiyama D, Kogata Y, Saegusa J, Sugimoto T, Kawano S, Morinobu A, Nishimura K, Kumagai S. Diagnostic accuracy of serum 1,3-β-D-glucan for pneumocystis jiroveci pneumonia, invasive candidiasis, and invasive aspergillosis: systematic review and meta-analysis. J Clin Microbiol. 2012;50(1):7–15.
Kopterides P, Tsangaris I. Procalcitonin and sepsis: recent data on diagnostic utility prognostic potential and therapeutic implications in critically ill patients. Minerva Anestesiol. 2012;78(7):823–35.
Costabel U, Uzaslan E, Guzman J. Bronchoalveolar lavage in drug-induced lung disease. Clin Chest Med. 2004;25(1):25–35.
Kondo K, Inoue Y, Hamada H, Yokoyama A, Kohno N, Hiwada K. Acetaminophen-induced eosinophilic pneumonia. Chest. 1993;104(1):291–2.
Ohnishi H, Yokoyama A, Yasuhara Y, Watanabe A, Naka T, Hamada H, Abe M, Nishimura K, Higaki J, Ikezoe J, Kohno N. Circulating KL-6 levels in patients with drug-induced pneumonitis. Thorax. 2003;58(10):872–5.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer Nature Singapore Pte Ltd.
About this chapter
Cite this chapter
Yokoyama, A. (2018). Differential Diagnoses of DLI: What Are the Differential Diagnoses of DLI?. In: Hanaoka, M., Nakamura, H., Aoshiba, K. (eds) Drug-Induced Lung Injury. Respiratory Disease Series: Diagnostic Tools and Disease Managements. Springer, Singapore. https://doi.org/10.1007/978-981-10-4466-3_8
Download citation
DOI: https://doi.org/10.1007/978-981-10-4466-3_8
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-10-4465-6
Online ISBN: 978-981-10-4466-3
eBook Packages: MedicineMedicine (R0)