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Diabetes and Female Sterility/Infertility

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Diabetes and Aging-related Complications

Abstract

AGEs (advanced glycation end products) are pro-inflammatory molecules that trigger a state of intracellular oxidative stress and inflammation after binding to their cell membrane receptors, such as RAGE. The activation of the AGE-RAGE axis has been well known to play a role in type 2 diabetes mellitus (T2DM), obesity, metabolic syndrome (MetS), cardiovascular disease (CVD), aging, inflammation, and neurodegenerative disorders. AGEs might contribute to the etiology of polycystic ovary syndrome and infertility. This article explains for the relationship between the AGE-RAGE system and infertility as well as ovarian reserve in women of reproductive age.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Nasu Red Cross Hospital, 1081-4 Nakadawara, Otawara, Tochigi, 324-8686, Japan

    Kuniaki Ota M.D., Ph.D. & Hiroaki Ohta

  2. Department of Pathophysiology and Therapeutics of Diabetic Vascular Complications, Kurume University School of Medicine, Kurume, 830-0011, Japan

    Sho-ichi Yamagishi

Authors
  1. Kuniaki Ota M.D., Ph.D.
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  2. Hiroaki Ohta
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  3. Sho-ichi Yamagishi
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Correspondence to Kuniaki Ota M.D., Ph.D. .

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Editors and Affiliations

  1. Department of Pathophysiology and Therapeutics of Diabetic Vascular Complications, Kurume University School of Medicine, Kurume, Fukuoka, Japan

    Sho-ichi Yamagishi

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© 2018 Springer Nature Singapore Pte Ltd.

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Ota, K., Ohta, H., Yamagishi, Si. (2018). Diabetes and Female Sterility/Infertility. In: Yamagishi, Si. (eds) Diabetes and Aging-related Complications. Springer, Singapore. https://doi.org/10.1007/978-981-10-4376-5_14

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  • DOI: https://doi.org/10.1007/978-981-10-4376-5_14

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-10-4375-8

  • Online ISBN: 978-981-10-4376-5

  • eBook Packages: MedicineMedicine (R0)

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