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Development of Microemulsion Containing Prednisolone

  • Minh Nguyet Pham
  • Toi Vo Van
  • Phuong Ha-Lien Tran
  • Thao Truong-Dinh Tran
Conference paper
Part of the IFMBE Proceedings book series (IFMBE, volume 63)

Abstract

Prednisolone, an anti-inflammatory drug with a very slight solubility (0.23 mg/mL at 25 °C), high permeability and short biological half-life (2–4 h) in oral administration was selected as the candidate drug for sustained drug release. The aim of this research is to formulate and evaluate the stable formation of oil-in-water microemulsion for enhancing the solubility of the model drug. Microemulsion containing oleic acid as oil component, Tween 20 and P188 as main surfactant and co-surfactant at different ratios were evaluated. The microemulsion was characterized by stability test, particle size, clarity, conductivity and pH value. A stable system at nano size (11.6 and 12.3 nm) which possibly enhanced drug solubility with no drug aggregation.

Keywords

Prednisolone Oil-in-water microemulsion Drug release 

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Notes

Acknowledgements

This research is partially funded by Vietnam National Foundation for Science and Technology Development (NAFOSTED) under grant number 106-YS.05-2015.02. We also thank to International University and Vietnam National University—Ho Chi Minh City for supporting to our research activities.

References

  1. 1.
    Ulbrich W, Lamprecht A (2009) Targeted drug-delivery approaches by nanoparticulate carriers in the therapy of inflammatory diseases. J R Soc Interface rsif20090285Google Scholar
  2. 2.
    Kumria R, Nair AB, Goomber G, Gupta S (2014) Buccal films of prednisolone with enhanced bioavailability. Drug Deliv 1–8Google Scholar
  3. 3.
    Jha SK (2012) Microemulsions-potential carrier for improved drug delivery. Asian J Biomed Pharm Sci 1:39–51Google Scholar
  4. 4.
    Kwak JC (1998) Polymer-surfactant systems, vol 77. CRC Press, Boca RatonGoogle Scholar
  5. 5.
    Sarkhejiya Naimish A, Nakum Mayur A, Patel Vipul P, Atara Samir A, Desai Thusarbindu R (2000) Emerging trend of microemulsion in formulation and research. Int Bull Drug Res 1:54–83Google Scholar
  6. 6.
    Rasal A, Mahajan H, Shaikh H, Surana S (2010) Development and characterization of nasal mucoadhesive microemulsion of sumatriptan succinate. Indian J Novel Drug Deliv 2:103–108Google Scholar
  7. 7.
    Nirmala MJ, Mukherjee A, Chandrasekaran N (2012) Enhanced solubilization of aqueous insoluble anti-hypertensive drug. Int J Pharm Pharm Sci 4:366–368Google Scholar
  8. 8.
    Sabale V, Vora S (2012) Formulation and evaluation of microemulsion-based hydrogel for topical delivery. Int j pharm inv 2:140CrossRefGoogle Scholar
  9. 9.
    Shafiq S, Shakeel F, Talegaonkar S, Ahmad FJ, Khar RK, Ali M (2007) Development and bioavailability assessment of ramipril nanoemulsion formulation. Eur J Pharm Biopharm 66:227–243CrossRefGoogle Scholar
  10. 10.
    Yadav S, Khatri J, Bhalerao S (2012) Development and evaluation of an ocular anti-inflammatory microemulsion. Int J Pharm Technol 4:4218–4230Google Scholar
  11. 11.
    Boonme P, Krauel K, Graf A, Rades T, Junyaprasert VB (2006) Characterization of microemulsion structures in the pseudoternary phase diagram of isopropyl palmitate/water/Brij 97: 1-butanol. AAPS PharmSciTech 7:E99–E104CrossRefGoogle Scholar
  12. 12.
    Agrawal OP, Agrawal S (2012) An overview of new drug delivery system: microemulsion. Asian J Pharm Sci Tech 2(1):5–12Google Scholar
  13. 13.
    Wang Z, Mu H-J, Zhang X-M, Ma P-K, Lian S-N, Zhang F-P et al (2015) Lower irritation microemulsion-based rotigotine gel: formulation optimization and in vitro and in vivo studies. Int J Nanomed 10:633Google Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  1. 1.Pharmaceutical Engineering Laboratory, Biomedical Engineering DepartmentInternational University, Vietnam National University—Ho Chi Minh CityHo Chi Minh CityVietnam
  2. 2.School of MedicineDeakin UniversityWaurn PondsAustralia

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