Controlled Nanonization of Poorly Water-Soluble Drugs for Reliable Bioavailability

Conference paper
Part of the IFMBE Proceedings book series (IFMBE, volume 63)

Abstract

Solid dispersions (SD) can be utilized to improve the dissolution rate of poorly water-soluble drugs and further to modulate the release pattern by selecting an appropriate hydrophilic polymer. SD overcomes the many solubility issues of various types of poorly water-soluble drugs, providing the medical benefits to obtain a reliable bioavailability. Controlled release (CR) systems offer several medical advantages, such as reducing the adverse effects, dosing frequency and ultimately enhancing the patient compliance. Thus, SD-loaded CR (SD-CR) systems provide some privileges in drug delivery by taking into consideration of solubilization and controlled release of poorly water soluble drugs for optimal therapy.

Keywords

Poorly water-soluble drugs Controlled release solid dispersion Solubilization mechanism Classification of solid dispersions Nanonization 

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Notes

Acknowledgements

This work was partially supported by a grant from the Ministry of Science, ICT and Future Planning, 2013 Patient-centric R&D Project (2013M3A9B5075841), Korea. Some of this information and Figures and Tables were extracted and cited from our previous publications.

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© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  1. 1.College of PharmacyAjou UniversitySuwonRepublic of Korea

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