Controlled Nanonization of Poorly Water-Soluble Drugs for Reliable Bioavailability

  • Beom-Jin Lee
Conference paper
Part of the IFMBE Proceedings book series (IFMBE, volume 63)


Solid dispersions (SD) can be utilized to improve the dissolution rate of poorly water-soluble drugs and further to modulate the release pattern by selecting an appropriate hydrophilic polymer. SD overcomes the many solubility issues of various types of poorly water-soluble drugs, providing the medical benefits to obtain a reliable bioavailability. Controlled release (CR) systems offer several medical advantages, such as reducing the adverse effects, dosing frequency and ultimately enhancing the patient compliance. Thus, SD-loaded CR (SD-CR) systems provide some privileges in drug delivery by taking into consideration of solubilization and controlled release of poorly water soluble drugs for optimal therapy.


Poorly water-soluble drugs Controlled release solid dispersion Solubilization mechanism Classification of solid dispersions Nanonization 


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This work was partially supported by a grant from the Ministry of Science, ICT and Future Planning, 2013 Patient-centric R&D Project (2013M3A9B5075841), Korea. Some of this information and Figures and Tables were extracted and cited from our previous publications.


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© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  1. 1.College of PharmacyAjou UniversitySuwonRepublic of Korea

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