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MicroRNAs Mediate Beneficial Effects of Exercise in Heart

Chapter
First Online:
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1000)

Abstract

MicroRNAs (miRNAs, miRs), a group of small non-coding RNAs, repress gene expressions at posttranscriptional level in most cases and are involved in cardiovascular physiology and disease pathogenesis. Increasing evidence has proved that miRNAs are potential regulators of exercise induced cardiac growth and mediate the benefits of exercise in a variety of cardiovascular diseases. In this chapter, we will review the regulatory effects of miRNAs in cardiac adaptations to exercise, and summarize their cardioprotective effects against myocardial infarction, ischemia/reperfusion injury, heart failure, diabetic cardiomyopathy, atherosclerosis, hypertension, and pulmonary hypertension. Also, we will introduce circulating miRNAs in response to acute and chronic exercise. Therefore, miRNAs may serve as novel therapeutic targets and potential biomarkers for cardiovascular diseases.

Keywords

MicroRNA Exercise Cardiovascular diseases 
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Notes

Acknowledgements

This work was supported by the grants from National Natural Science Foundation of China (81570362, 91639101 and 81200169 to JJ Xiao and 81400647 to Y Bei), and the development fund for Shanghai talents (to JJ Xiao), Innovation Program of Shanghai Municipal Education Commission (2017-01-07-00-09-E00042), the grant from Science and Technology Commission of Shanghai Municipality (17010500100).

Competing Financial Interests

The authors declare no competing financial interests.

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© Springer Nature Singapore Pte Ltd. 2017

Authors and Affiliations

  1. 1.Cardiac Regeneration and Ageing Lab, School of Life ScienceShanghai UniversityShanghaiChina
  2. 2.Department of CardiologyThe Third Affiliated Hospital of Soochow UniversityChangzhouChina
  3. 3.Victor Babes National Institute of PathologyBucharestRomania
  4. 4.Division of Cellular and Molecular Biology and HistologyCarol Davila University of Medicine and PharmacyBucharestRomania

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