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C/EBPB-CITED4 in Exercised Heart

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Exercise for Cardiovascular Disease Prevention and Treatment

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1000))

Abstract

C/EBPB is a crucial transcription factor, participating in a variety of biological processes including cell proliferation, differentiation and development. In the cardiovascular system, C/EBPB-CITED4 signaling is known as a signaling pathway mediating exercise-induced cardiac growth. After its exact role in exercised heart firstly reported in 2010, more and more evidence confirmed that. MicroRNA (e.g. miR-222) and many molecules (e.g. Alpha-lipoic acid) can regulate this pathway and then involve in the cardiac protection effect induced by endurance exercise training. In addition, in cardiac growth during pregnancy, C/EBPB is also a required regulator. This chapter will give an introduction of the C/EBPB-CITED4 signaling and the regulatory network based on this signaling pathway in exercised heart.

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The authors declare no competing financial interests.

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Author notes

  1. Shengguang Ding, Tianyi Gan and Meiyi Song contributed equally to this work.

Authors and Affiliations

  1. Department of Thoracic and Cardiovascular Surgery, The Second Affiliated Hospital of Nantong University, Nantong, 226001, China

    Shengguang Ding, Haitao Huang, Yiming Xu & Chongjun Zhong

  2. State Key Laboratory of Cardiovascular Disease, Heart Failure Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China

    Tianyi Gan

  3. Division of Gastroenterology and Hepatology, Digestive Disease Institute, Shanghai Tongji Hospital, Tongji University School of Medicine, 389 Xin Cun Road, Shanghai, 200065, China

    Meiyi Song

  4. Metrowest Medical Center, Framingham, 01702, MA, USA

    Qiying Dai

  5. Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China

    Qiying Dai

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  1. Shengguang Ding
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Correspondence to Chongjun Zhong .

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  1. Cardiac Regeneration and Ageing Lab, School of Life Science, Shanghai University, Shanghai, China

    Junjie Xiao

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Ding, S. et al. (2017). C/EBPB-CITED4 in Exercised Heart. In: Xiao, J. (eds) Exercise for Cardiovascular Disease Prevention and Treatment. Advances in Experimental Medicine and Biology, vol 1000. Springer, Singapore. https://doi.org/10.1007/978-981-10-4304-8_14

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