Therapeutic Enzymes

  • Swaroop S. Kumar
  • Sabu AbdulhameedEmail author


Enzymes as therapeutics hold a few advantages over non-enzymatic drugs with their amazing specificity towards targets as well as multiple substrate conversion. Development of enzyme therapeutics against rare diseases such as lysosomal storage disorders and severe combined immunodeficiency undoubtedly raised the hope of patients and improved their quality of life. Development of enzyme therapeutics against cardiovascular diseases witnessed a tremendous explosion in the past four to five decades and resulted in the development of the first approved genetically engineered drug against cardiovascular diseases (Activase®). Since then many recombinant cardiovascular drugs have been approved for clinical application. Often immunogenicity associated with enzyme drugs and the cost of production are major setbacks for their development. Despite their advantages only a few enzymes were approved by the Food and Drug Administration (FDA).


Therapeutic enzymes Plasminogen activators Staphylokinase Nattokinase Velaglucerase alfa Alglucosidase alfa Serrapeptase Rasburicase 


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© Springer Nature Singapore Pte Ltd. 2017

Authors and Affiliations

  1. 1.Department of Biotechnology and Microbiology, School of Life SciencesKannur UniversityKannurIndia
  2. 2.Inter University Centre for Bioscience, Department of Biotechnology and Microbiology, School of Life SciencesKannur UniversityKannurIndia

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