Novel Targets and Advancements in Drug Discovery: The Case of HIV-AIDS

  • Nihar Ranjan
  • Umesh Kumar
  • Sunil K. Deshmukh


Since the very first report of acquired immune deficiency syndrome (AIDS) in the early 1980s in the United States, a number of advancements have taken place both in the structural and functional aspects of the human immunodeficiency virus (HIV) life cycle as well as anti-HIV drug design. While new drugs have come to the market and combination therapies have increased life expectancy, resistance and viral mutations have mandated introduction of new drugs in the market. Apart from two main classes of HIV inhibitors (reverse transcriptase and protease), new inhibitors targeting fusion and integration processes have provided additional sites for therapy development. More recently inhibitors of maturation and capsid assembly as well as viral replication have been studied to provide novel anti-HIV drugs. In this chapter, we briefly discuss the HIV life cycle and describe a few of the recent endeavors made to develop new anti-HIV agents. For brevity, we provide a limited number of examples of discoveries made in the main target sites of current HIV drug design.


Novel targets HIV Reverse transcriptase Antiviral drug 


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Copyright information

© Springer Nature Singapore Pte Ltd. 2017

Authors and Affiliations

  1. 1.TERI-Deakin Nanobiotechnology CenterThe Energy and Resources Institute, TERI GramGurugramIndia

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