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Quorum Quenching Compounds from Natural Sources

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Bioresources and Bioprocess in Biotechnology

Abstract

Quorum sensing is a process of bacterial communication system wherein the production and secretion of small signaling molecules known as autoinducers enables the bacteria to express specific genes at particular population densities. Quorum quenching (QQ) can be used as an alternative approach to regulate pathogenicity. Well-established QQ strategies include amide bond hydrolysis, lactone hydrolysis, paraoxonase enzymes, and QQ modification of acyl chain. Plants in general lack advanced immune systems, and may have evolved to produce QQ compounds to combat with plant invading pathogens. Most common sources of QQ compounds in marine environment are bacteria, fungi, algae, bryozoan, corals, and sponges. Marine cyanobacteria have become one among the best source for obtaining biologically active and structurally unique QQ natural products. QQ compounds are being innovated as alternatives of antibiotics to treat pathogenic infections. Marine ecosystem is a unique and unexplored hotspot for the development of new derivatives of potential QQ compounds.

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Authors and Affiliations

  1. Department of Food Science and Technology, Pondicherry University, Puducherry, 605014, India

    G. Seghal Kiran & Arya Sajayan

  2. Department of Microbiology, School of Life Sciences, Pondicherry University, Puducherry, 605014, India

    Saqib Hassan & Joseph Selvin

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  1. G. Seghal Kiran
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  2. Saqib Hassan
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  3. Arya Sajayan
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  4. Joseph Selvin
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Correspondence to G. Seghal Kiran .

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  1. Microbiology Division, Jawaharlal Nehru Tropical Botanic Garden, Thiruvananthapuram, Kerala, India

    Shiburaj Sugathan

  2. Microbiology Division, Jawaharlal Nehru Tropical Botanic Garden, Thiruvananthapuram, Kerala, India

    N. S. Pradeep

  3. Inter University Centre for Bioscience, Department of Biotechnology and Microbiology, School of Life Sciences, Kannur University, Kannur, Kerala, India

    Sabu Abdulhameed

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Seghal Kiran, G., Hassan, S., Sajayan, A., Selvin, J. (2017). Quorum Quenching Compounds from Natural Sources. In: Sugathan, S., Pradeep, N., Abdulhameed, S. (eds) Bioresources and Bioprocess in Biotechnology. Springer, Singapore. https://doi.org/10.1007/978-981-10-4284-3_14

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