CMBEBIH 2017 pp 269-274 | Cite as

Computational modeling of plaque development in the coronary arteries

Conference paper
Part of the IFMBE Proceedings book series (IFMBE, volume 62)


Computational study for plaque formation and development for the patient specific coronary arteries was performed. Transport of macrophages and oxidized LDL distribution for the initial plaque grow model inside the intimal area was implemented. Mass transport of LDL through the wall and the simplified inflammatory process was firstly solved. The Navier-Stokes equations govern the blood motion in the lumen, the Darcy law is used for model blood filtration, Kedem-Katchalsky equations for the solute and flux exchanges between the lumen and the intima. The system of three additional reaction-diffusion equations that models the inflammatory process and lesion growth model in the intima was used. Some examples of computer simulation for plaque formation and progression for the specific patient for left and right coronary arteries are presented. Determination of plaque location and plaque volume with computer simulation for a specific patient shows a potential benefit for prediction of disease progression.


Wall Shear Stress Plaque Formation Shear Stress Distribution Plaque Volume Oscillatory Shear Index 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Nature Singapore Pte Ltd. 2017

Authors and Affiliations

  1. 1.Faculty of EngineeringUniversity of KragujevacKragujevacSerbia
  2. 2.BioIRC Bioengineering Research and Development CenterKragujevacSerbia
  3. 3.University of IoanninaIoanninaGreece
  4. 4.National Research Council PisaPisaItaly

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