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An Age-based Multiscale Mathematical Model of the Hepatitis C Virus Life-cycle During Infection and Therapy: Including Translation and Replication

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VII Latin American Congress on Biomedical Engineering CLAIB 2016, Bucaramanga, Santander, Colombia, October 26th -28th, 2016

Part of the book series: IFMBE Proceedings ((IFMBE,volume 60))

Abstract

The dynamics of hepatitis C virus (HCV) RNA during translation and replication were added to an age-based multiscale mathematical model of HCV infection and treatment. The model allows the study of the production of HCV inside infected cells, which are later released as virus in the plasma, available to infect other cells. This is the first model to our knowledge to consider both positive and negative strands of HCV RNA with an age-based multiscale approach. Simulation of the effectiveness of direct acting antiviral (DAA) drugs in blocking HCV RNA intracellular production and release of new virions, and enhancing their depletion were performed. Changes on the set of parameters allowed the validation of the model comparing it to distinct experiments: in vitro and in vivo under therapy.

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Author information

Authors and Affiliations

  1. Pós-Graduação em Modelagem Computacional, Universidade Federal de Juiz de Fora, Juiz de Fora, Brazil

    B. M. Quintela, R. F. Reis, R. W. dos Santos & M. Lobosco

  2. Department of Mathematics, The Pennsylvania State University, University Park, State College, USA

    J. M. Conway

  3. Mathematics Department, Tulane University, New Orleans, USA

    J. M. Hyman

  4. Los Alamos National Laboratory, Theoretical Biology and Biophysics, Los Alamos, USA

    A. S. Perelson

Authors
  1. B. M. Quintela
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  2. J. M. Conway
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  3. J. M. Hyman
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  4. R. F. Reis
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  5. R. W. dos Santos
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  6. M. Lobosco
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  7. A. S. Perelson
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Editor information

Editors and Affiliations

  1. Asociación Colombiana de Bioingeniería y Electrónica Médica - ABIOIN, Bucamaranga, Colombia

    Isnardo Torres

  2. Universidad Pontificia Bolivariana - UPB, Centro de Bioingeniería, Medellín, Colombia

    John Bustamante

  3. Universidad Industrial de Santander, Escuela de Ing. Eléctrica, Electrónica, Bucaramanga, Colombia

    Daniel A. Sierra

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Quintela, B.M. et al. (2017). An Age-based Multiscale Mathematical Model of the Hepatitis C Virus Life-cycle During Infection and Therapy: Including Translation and Replication. In: Torres, I., Bustamante, J., Sierra, D. (eds) VII Latin American Congress on Biomedical Engineering CLAIB 2016, Bucaramanga, Santander, Colombia, October 26th -28th, 2016. IFMBE Proceedings, vol 60. Springer, Singapore. https://doi.org/10.1007/978-981-10-4086-3_128

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  • DOI: https://doi.org/10.1007/978-981-10-4086-3_128

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-10-4085-6

  • Online ISBN: 978-981-10-4086-3

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