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Personalized Intraperitoneal Strategies in Gastric Cancer

  • Yang Yang
  • Nandie Wu
  • Jia Wei
Chapter

Abstract

Gastric cancer is the fourth most common cancer and the second leading cause of cancer deaths worldwide [1]. Except countries such as Korea and Japan that have routine national screening programs, most patients with gastric cancer are in advanced stages of the disease as early-stage gastric cancers are usually without symptoms and often develop advanced stage even after radical surgery. Despite developments in the surgical treatment of gastric cancer, there is a relatively high recurrence rate. Specifically, the 5-year overall survival rate for all diagnosed patients averages 24.5% in Europe [2] and 40–60% in Asia [3, 4]. The main reason for post-surgery treatment failure for gastric cancer is peritoneal dissemination, which is caused by the seeding of free cancer cells from the primary gastric cancer. This is one of the most common types of metastasis for gastric cancer. Gastric cancer patients with macroscopic peritoneal metastasis have very poor prognoses, with a median overall survival of 3–6 months [5, 6]. In this chapter, we try to describe the influence of peritoneal metastasis on survival in patients with gastric cancer, the possible mechanism of peritoneal metastasis, and individualized treatment strategy of gastric cancer patients at high risk for developing peritoneal metastasis.

Keywords

Gastric Cancer Gastric Cancer Cell Gastric Cancer Patient Peritoneal Carcinomatosis Peritoneal Metastasis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Nature Singapore Pte Ltd. 2017

Authors and Affiliations

  • Yang Yang
    • 1
  • Nandie Wu
    • 1
  • Jia Wei
    • 1
  1. 1.The Comprehensive Cancer Centre of Drum Tower HospitalMedical School of Nanjing University and Clinical Cancer Institute of Nanjing UniversityNanjingChina

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