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Circulating Tumor Cells in Gastric Cancer

  • Jie ShenEmail author
  • Lifeng Wang
Chapter

Abstract

Historically, tumor tissue has been the major source of material used for cancer biomarker evaluation. However, several situations arise where there is a shortage of tissue needed for such tumor tissue-based detection strategies. First, it may be impossible to obtain tissue from advanced case patients. Tissues from biopsy may not always be enough for gene detection. Second, tumor tissue obtained at the time of the initial diagnosis might not reflect alterations of genetic profile observed at the time of clinical progression, because primary and metastatic tumors from the same person can be diffident at levels of genomic, transcriptomic, and epigenetic. Moreover, chemotherapy or targeted therapy may alter gene expression level itself. In such cases, circulating tumor cells could be a noninvasive and useful tool for tracking changes and providing useful and timely information for determining the best course of treatment. It could also be useful for those who do not have enough tissue for adequate gene detection when neoadjuvant or adjuvant chemotherapy needs to be chosen.

Keywords

Gastric Cancer Advanced Gastric Cancer Circulate Tumor Cell Immunocompromised Mouse Peripheral Mononuclear Blood 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Nature Singapore Pte Ltd. 2017

Authors and Affiliations

  1. 1.The Comprehensive Cancer Centre of Drum Tower HospitalMedical School of Nanjing University and Clinical Cancer Institute of Nanjing UniversityNanjingChina

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