Aging Voice pp 75-82 | Cite as

Fat Injection for Voice Improvement in Atrophic Vocal Folds

  • Etsuyo Tamura


With the incidence of geriatric dysphonia expected to rise in conjunction with the aging population in Japan, we propose a vocal fold injection augmentation technique with autologous fat for vocal improvement. Vocal fold injection augmentation is a safe, simple procedure that can improve quality of life (QOL) by enabling vocal improvement within a shorter period than voice training, without the need for open surgery. Between April 2012 and March 2016, we performed vocal fold injection augmentation with autologous fat under general anesthesia for 18 men and 3 women (mean age, 66 years; range, 60–79 years). Buccal fat tissue was used for the injection; therefore, no skin incisions were required. Evaluation following fat injection was based on maximum phonation time, auditory impression (GRBAS; G: grade of hoarseness, R: rough, B: breathy, A: asthenic, S: strained), and Voice Handicap Index-10 (VHI10) score. Auditory impression improved significantly and VHI10 score also tended to improve after injection. Vocal fold injection augmentation technique with autologous fat is minimally invasive, does not require the use of biologically foreign material, and appears effective for improving voice and QOL by enhancing the vocal folds of elderly individuals.


Vocal Fold Glottal Closure Maximum Phonation Time Buccinator Muscle Unilateral Recurrent Laryngeal Nerve Paralysis 
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  1. 1.
    Sokabe M. Basics of mechanobiology in regenerative medicine. Regen Med. 2014;13:30–47.Google Scholar
  2. 2.
    Mikaelian DO, Lowry LD, Sataloff RT. Lipoinjection for unilateral vocal cord paralysis. Laryngoscope. 1991;101:465–8.PubMedGoogle Scholar
  3. 3.
    Chan WD, Titze IR. Viscosities of injectable biomaterials in vocal fold augmentation surgery. Laryngoscope. 1998;108:725–31.CrossRefPubMedGoogle Scholar
  4. 4.
    Tamura E, Fukuda H, Tabata Y, Nishimura M. Use of the buccal fat pad for vocal cord augmentation. Acta Otolaryngol. 2008;128:219–24.CrossRefPubMedGoogle Scholar
  5. 5.
    Bichat F. Anatomie generale appliqué a la physiologie et a la medecine. Paris: Grosson: Gabon et Cie; 1802.Google Scholar
  6. 6.
    Stuzin JM, Wagstrom L, Kawamoto HK, Baker TJ, Wolfe SA. The anatomy and clinical application of the buccal fat pad. Plast Reconstr Surg. 1990;85:29–36.CrossRefPubMedGoogle Scholar
  7. 7.
    Zhang HM, Yan YP, Qi KM, Wang JQ, Liu ZF. Anatomical structure of the buccal fat pad and its clinical adaptations. Plast Reconstr Surg. 2002;109:2509–18.CrossRefPubMedGoogle Scholar
  8. 8.
    Tamura E, Okada S, Shibuya M, Iida M. Comparison of fat tissues in intracordal aitologousu fat injection. Acta Otolaryngol. 2010;130:405–9.CrossRefPubMedGoogle Scholar
  9. 9.
    Matarasso A. Buccal fat pad Excision: aeshtetic improvement of the midface. Ann Plast Surg. 1991;26:413–8.CrossRefPubMedGoogle Scholar
  10. 10.
    Beskow J, Sjölander K. WaveSurfer – an open source speech tool. In Proceedings of ICSLP-2000, 2000 ; 4: 464–467.

Copyright information

© Springer Nature Singapore Pte Ltd. 2017

Authors and Affiliations

  1. 1.Department of Otorhinolaryngology, Tokai University School of MedicineTokai University Tokyo HospitalTokyoJapan

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