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Chitosan-Based Nanoparticulate Systems: Implication Towards Therapeutics Application

  • Anurag Dobhal
  • Prachi Bangde
  • Anomitra Dey
  • Prajakta Dandekar
  • Ratnesh Jain
Chapter

Abstract

Recently polymeric nanoparticulate systems have gained a great impetus in the biopharmaceutical research, primarily due to their ability to enhance the pharmacokinetics and pharmacodynamics of various drugs and bioactives. Some of these polymeric systems render an improved biodegradability and biocompatible properties. There is a wide array of natural and synthetic polymers that have been utilized to develop various nanocarriers for delivery of drugs, genes, and other bioactive compounds. Polymeric nanoparticles offer moderately high encapsulation efficiency, along with enhancement of stealth properties in the circulatory system when suitably surface modified, which further ensures a sustained release of the encapsulated agent. Moreover, the polymeric nanoparticles have a mesh-like framework that can accommodate bioactive materials along with a drug moiety forming a dual delivery system, which can be further coated with another polymer giving rise to core–shell nano-conjugate system to offer better targeting of drugs/genes and bioactives. Chitosan and their chitosan derivatives have found applications in various delivery systems. Chitosan is one of the abundant biopolymers existing in nature, which has made it a polymer of choice in various drug delivery applications. This chapter focuses on the practical considerations for development of chitosan nanoparticles, along with a detailed account of various genes and bioactives that may be encapsulated or loaded on to them. Further, emphasis will be given on the physicochemical behavior of such systems and their subsequent cellular responses, besides their biodistribution and toxicity profiles. The discussion will also highlight the implication of polymeric nanoparticles in various therapies and limitations pertaining to them. The manuscript will also address the commercial status of polymeric nanoparticles.

Keywords

Chitosan Nanoparticles Drug delivery Gene delivery and protein delivery 

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© Springer Nature Singapore Pte Ltd. 2017

Authors and Affiliations

  1. 1.Department of Chemical EngineeringInstitute of Chemical TechnologyMumbaiIndia
  2. 2.Department of Pharmaceutical Science and TechnologyInstitute of Chemical TechnologyMumbaiIndia

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