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Benign Tumors of the Liver and Intrahepatic Bile Duct

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Book cover Surgical Pathology of Hepatobiliary Tumors

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Abstract

Hepatocellular adenoma (HCA) is a benign tumor derived from hepatocytes, the incidence of which is 3–4/100,000 in Europe and North America; most of the patients are female with administration of oral contraceptives, and women account for 85% of all the patients [1]. In Western countries, contraceptives have been considered as a key cause for HCA, and studies have shown that HCA will decrease in sizes in patients who have a history of taking some of the oral contraceptives after they stop them [2]. Androgen is another potential cause for HCA [3]. Hereditary metabolic diseases, hepato-glycogenosis [4], maturity-onset diabetes of young type 3 (MODY3) [5], familial adenomatous polyposis (FAP), and hemoglobin deposition are all associated with the onset of HCA. Several researches have proposed abroad that obesity is also a key factor with an impact on the genesis of HCA [6, 7]. In addition, the relationship between alcohol and HCA should also be paid more attention. However, the epidemiological situation of the disease in China is different from that in the Western countries. According to the statistics from the Department of Pathology, East Hepatobiliary Surgery Hospital, Second Military Medical University, among the 189 cases with surgical resection of HCA, middle-aged male patients account for 70% of all the patients, and 50% of the patients are overweight or obese, while female patients rarely have a history of oral contraceptive administration [8], suggesting the difference in the pathogenesis and prevalence populations of HCA between China and Occidental countries which deserves further study.

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  1. Department of Pathology, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China

    Wen-Ming Cong, Qian Zhao, Xin-Yuan Lu, Xia Sheng, Long-Hai Feng & Yu-Yao Zhu

  2. Zhong-shan Hospital, Fudan University, Shanghai, China

    Yuan Ji

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Cong, WM. et al. (2017). Benign Tumors of the Liver and Intrahepatic Bile Duct. In: Cong, WM. (eds) Surgical Pathology of Hepatobiliary Tumors. Springer, Singapore. https://doi.org/10.1007/978-981-10-3536-4_6

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