Abstract
Aromatics composed of benzene, naphthalene, heteroarene etc., are useful backbones in various scientific fields, such as the pharmaceutical and material chemistries. Iron (Fe) metal is one of the bountiful resources on the earth and iron trichloride (FeCl3) is widely utilized as an inexpensive and commercially available reagent for organic synthesis. Meanwhile, the reactions generating neutral wastes and/or reducing wastes are valuable methods from the viewpoint of green chemistry. We have continuously investigated the FeCl3-catalyzed benzylic activations of various substrates to construct highly-functionalized aromatics. The reactions that only generate water, methanol or silanol derived from substrates as a neutral waste are regarded to be environmentally friendly and green sustainable in comparison with the similar reported reactions, which generate acidic waste and/or require the use of rare metals. In this review, our recent results, related to the chemo-selective transformations and construction of highly-substituted aromatics, etc., are summarized.
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Sawama, Y. (2017). Environment-Friendly Iron-Catalyzed Reactions. In: Tomioka, K., Shioiri, T., Sajiki, H. (eds) New Horizons of Process Chemistry. Springer, Singapore. https://doi.org/10.1007/978-981-10-3421-3_5
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DOI: https://doi.org/10.1007/978-981-10-3421-3_5
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