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The Role of Ribosome Biogenesis in Skeletal Muscle Hypertrophy

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The Plasticity of Skeletal Muscle

Abstract

The regulation of muscle size is primarily determined by protein metabolism. During periods of rapid muscle wasting, protein degradation has a major role, whereas during muscle hypertrophy the main force driving the increase in myofiber size is muscle protein synthesis. Although the majority of studies to date have focused on the short-lived responses in protein synthesis following an acute bout of resistance exercise, accumulating evidences in recent years have convincingly demonstrated that ribosome biogenesis as a main source of translational capacity plays an important role in muscle growth. This chapter will focus on muscle ribosome biogenesis in relation to the biology of muscle growth and its important implications for clinical studies.

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Authors and Affiliations

  1. Center for Muscle Biology, University of Kentucky, Lexington, KY, USA

    Vandre Casagrande Figueiredo & John J. McCarthy

  2. College of Health Sciences, University of Kentucky, Lexington, KY, USA

    Vandre Casagrande Figueiredo

  3. Department of Physiology, College of Medicine, University of Kentucky, Lexington, KY, USA

    John J. McCarthy

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  1. Vandre Casagrande Figueiredo
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Correspondence to John J. McCarthy .

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  1. Institute for Liberal Arts, Environment and Society, Tokyo Institute of Technology, Tokyo, Japan

    Kunihiro Sakuma

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Figueiredo, V.C., McCarthy, J.J. (2017). The Role of Ribosome Biogenesis in Skeletal Muscle Hypertrophy. In: Sakuma, K. (eds) The Plasticity of Skeletal Muscle. Springer, Singapore. https://doi.org/10.1007/978-981-10-3292-9_6

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  • DOI: https://doi.org/10.1007/978-981-10-3292-9_6

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