Abstract
Iron, the most abundant transition metal on earth, has so far not received enough attention in catalytic organic synthesis because the catalytic activity of organoiron species is often difficult to control, resulting in narrow applicability. We report here that an iron-catalyzed C–H functionalization reaction allows the coupling of a wide variety of combinations of aromatic, heteroaromatic and olefinic substrates, and alkenyl, alkyl and aryl boron compounds among the reactions catalyzed by precious metals such as palladium. We rationalize these results by the involvement of an organoiron(III) reactive intermediate that is responsible for the C–H bond activation process, and a metal-to-ligand charge transfer that enables smooth catalytic turnover via an iron(I) intermediate.
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Shang, R. (2017). Iron-Catalyzed Directed C(sp2)–H Bond Functionalization with Organoboron Compounds. In: New Carbon–Carbon Coupling Reactions Based on Decarboxylation and Iron-Catalyzed C–H Activation. Springer Theses. Springer, Singapore. https://doi.org/10.1007/978-981-10-3193-9_11
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DOI: https://doi.org/10.1007/978-981-10-3193-9_11
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