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Pathophysiology of Endometrial Carcinoma

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Abstract

Endometrial adenocarcinoma may be preceded by endometrial hyperplasia.

Oestrogen has been associated with increased endometrial hyperplasia and adenocarcinoma.

It is divided into two classes, type I and type II, each with different pathophysiology, genetic alterations and prognosis.

Histologically endometrioid morphology accounts for 75–80 % of cases.

In addition to tumour type, the tumour grade and surgical stage influence the prognosis.

Immunohistochemistry is useful in the diagnosis of endometrial carcinomas only in some specific situations.

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Authors and Affiliations

  1. Sawai Man Singh Medical College and attached hospitals, Jaipur, India

    Arpita Jindal MD

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  1. Arpita Jindal MD
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Correspondence to Arpita Jindal MD .

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Editors and Affiliations

  1. Gynecologic Oncology, Bhagwan Mahaveer Cancer Hospital and Research Centre, Jaipur, India

    Ranu Patni

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Jindal, A. (2017). Pathophysiology of Endometrial Carcinoma. In: Patni, R. (eds) Current Concepts in Endometrial Cancer. Springer, Singapore. https://doi.org/10.1007/978-981-10-3108-3_4

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  • DOI: https://doi.org/10.1007/978-981-10-3108-3_4

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-10-3107-6

  • Online ISBN: 978-981-10-3108-3

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