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Case Study: 3D Printed Cartilage

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Biomaterials for Musculoskeletal Regeneration

Part of the book series: Indian Institute of Metals Series ((IIMS))

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Abstract

In the past decade, cartilage tissue engineering research envisaged on the development of engineered constructs to repair cartilage defects, which could be inflicted due to degenerative disease or traumatic injury. However, despite significant efforts, development of load bearing functional cartilage remains elusive. 3D bioprinting offers a fascinating approach to replicate the complex anatomical cartilaginous tissue architecture by precise delivery of encapsulated cells and morphogens at pre-determined location. Silk fibroin protein can be used for cartilage 3D bioprinting, as it possesses unique features such as shear thinning behaviour, self-supporting filamentous extrusion, instant cytocompatible sol-to-gel transition and tailorable mechanical strength. But systematic optimization of chemistry and rheology of bioink, topographical, physico-chemical and biomechanical functionality of printed cartilage constructs should be done to achieve this target. In this chapter we tried to summarize how chondrogenic differentiation is supported in 3D printed construct and signaling mechanisms minimizing hypertrophic differentiation of progenitor cells towards development of phenotypically stable engineered cartilage constructs.

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Authors and Affiliations

  1. Indian Institute of Science, Bangalore, Karnataka, India

    Bikramjit Basu

  2. Indian Institute of Technology Delhi, New Delhi, Delhi, India

    Sourabh Ghosh

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  1. Bikramjit Basu
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  2. Sourabh Ghosh
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Correspondence to Sourabh Ghosh .

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Basu, B., Ghosh, S. (2017). Case Study: 3D Printed Cartilage. In: Biomaterials for Musculoskeletal Regeneration. Indian Institute of Metals Series. Springer, Singapore. https://doi.org/10.1007/978-981-10-3017-8_8

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