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Bone marrow stem cell therapy for stroke pp 55–79Cite as

Mobilization and Homing of Bone Marrow Stem Cells After Stroke

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Abstract

Generally, bone marrow stem cells (BMSCs) reside in the bone marrow, where the microenvironments maintain a dynamic balance between self-renewal and differentiation. However, BMSCs can also be forced into the blood, a process termed mobilization, which is clinically used to harvest large number of cells for transplantation. On the other side, stroke-induced local and systemic pathological responses also lead to the mobilization of BMSCs to peripheral blood and then “homing” to the damaged regions, which is considered as an important regenerative process. In this chapter, we summarize current understanding of the physiological and pathological mechanisms that guide BMSC mobilization and homing to the damaged brain. The underlying cellular and molecular mechanisms, which largely depend on an interplay between chemokines, chemokine receptors, intracellular signaling, adhesion molecules, and proteases, are also discussed. Increasing the number of BMSC mobilization and homing is critical for the promotion of stroke cell-based therapies.

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Authors and Affiliations

  1. Zhejiang Provincial Key Laboratory of Aging and Neurological Disorder Research, First Affiliated Hospital, Wenzhou Medical University, Wenzhou City, Zhejiang Province, 325000, People’s Republic of China

    Weikai Wang, Lefu Chen, Linhui Ruan & Kunlin Jin

  2. Department of Pharmacology Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, USA

    Kunlin Jin

  3. Department of Neurosurgery, First Affiliated Hospital, Wenzhou Medical University, Wenzhou, China

    Qichuan Zhuge

  4. Zhejiang Provincial Key Laboratory of Aging and Neurological Disorder Research, First Affiliated Hospital, Wenzhou Medical University, Wenzhou, China

    Qichuan Zhuge

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  1. Weikai Wang
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  2. Lefu Chen
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  3. Linhui Ruan
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  4. Kunlin Jin
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  5. Qichuan Zhuge
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Correspondence to Qichuan Zhuge .

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  1. Department of Pharmacology Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas, USA

    Kunlin Jin

  2. Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, Beijing, China

    Xunming Ji

  3. Department of Neurosurgery First Affiliated Hospital, Wenzhou Medical University, Wenzhou, China

    Qichuan Zhuge

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Wang, W., Chen, L., Ruan, L., Jin, K., Zhuge, Q. (2017). Mobilization and Homing of Bone Marrow Stem Cells After Stroke. In: Jin, K., Ji, X., Zhuge, Q. (eds) Bone marrow stem cell therapy for stroke. Springer, Singapore. https://doi.org/10.1007/978-981-10-2929-5_3

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