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Ischemic Stroke Pathophysiology and Cell Therapy

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Bone marrow stem cell therapy for stroke

Abstract

Current evidence shows great promise for stem cell transplantation as a new therapeutic strategy for stroke. However, stem cell transplantation for stroke is still in its infancy, with many issues that need to be addressed in order to achieve the full potential of stem cell therapy for stroke. Among the major hurdles for successful clinical translation is determining the therapeutic time window, stem cell type selection, delivery route, and underlying cellular and molecular mechanisms. In this chapter, we attempt to review the basic knowledge of pathophysiology and summarize the different stem cells for stroke treatment.

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Authors and Affiliations

  1. Institute of Hypoxia Medicine, Xuanwu Hospital, Capital Medical University, Chang Chun Road 45, Beijing, 100053, China

    Changhong Ren & Rongrong Han

  2. China-America Joint Institute for Neuroscience, Xuanwu Hospital, Capital medical University, Chang Chun Road 45, Beijing, 100053, China

    Jingfei Shi

  3. Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China

    Xunming Ji

  4. Institute of Hypoxia Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China

    Xunming Ji

  5. China-America Joint Institute for Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, China

    Xunming Ji

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  1. Changhong Ren
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  1. Department of Pharmacology Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas, USA

    Kunlin Jin

  2. Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, Beijing, China

    Xunming Ji

  3. Department of Neurosurgery First Affiliated Hospital, Wenzhou Medical University, Wenzhou, China

    Qichuan Zhuge

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Ren, C., Han, R., Shi, J., Ji, X. (2017). Ischemic Stroke Pathophysiology and Cell Therapy. In: Jin, K., Ji, X., Zhuge, Q. (eds) Bone marrow stem cell therapy for stroke. Springer, Singapore. https://doi.org/10.1007/978-981-10-2929-5_1

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